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Antimalarial Drugs I - Biological Background, Experimental Methods, and Drug Resistance (Paperback, Softcover reprint of the original 1st ed. 1984)
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Antimalarial Drugs I - Biological Background, Experimental Methods, and Drug Resistance (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: Handbook of Experimental Pharmacology, 68 / 1
Expected to ship within 10 - 15 working days
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Of all the parasitic diseases that beset man in the warmer parts of
the world, malaria is still the major cause of morbidity and
mortality. In spite of intensive efforts to interrrupt its
transmission malaria still threatens over 800 million people, more
than one-fifth of the world's population. Malignant tertian malaria
caused by Plasmodium Jalciparum probably kills a million every
year. Vivax malaria temporarily incapacitates millions more. The
search for antimalarial drugs, both natural and syn. thetic, has
been and continues to be one of the most challenging and, at times,
rewarding exercises ever undertaken by ;:;hemists and biologists.
The magnitude of the effort is reflected by the fact that, in the
last 15 years, well over 250000 compounds have been screened for
antimalarial activity in just one programme, that carried out under
the auspices of the Walter Reed Army Institute of Research, not to
mention sporadic studies undertaken by other research workers and
organisations. While most people engaged in the search for new
drugs agree that a rational approach based on knowledge of the
intimate biochemical pathways of the target cells would be ideal as
well as intellectually satisfying, most are reluctantly obliged to
concede that, up to the present time, the chances of success
following a more or less empirical search have been far greater.
Spectacular advances in molecular biology and biochemistry in
recent years, however, are rapidly changing this situation.
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