The present study was undertaken to develop oral sustained release
tablets of metoprolol tartrate using natural hydrophilic matrix
formers (xanthan gum and tragacanth). Sustained release matrix
tablets of metoprolol tartrate were prepared by using different
ratios of drug, xanthan gum and tragacanth. Microcrystalline
cellulose (MCC) was used as diluent. The polymer was incorporated
into a matrix system using direct compression technique. Different
formulations were evaluated with respect to dissolution profile in
900 mL phosphate buffer (pH 6.8), 0.1 M HCl solution and distilled
water for 12 h at 37 C. Increasing the amount of polymer (xanthan
gum) in the formulation led to slow release of drug. The kinetic
treatment showed the best fitted different mathematical models
(Zero order, First order, Higuchiis and Hixson-Crowell). Most of
the solid matrix formulations followed Higuchi or zero order
kinetics. The formulations F1, F2, F3 and F7, F8, F9 showed maximum
linearity. The results showed that the formulation F9 containing
30% xanthan gum and 10% gum tragacanth is the most similar to that
of the reference marketed preparation.
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