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Neurobiology of the Trace Amines - Analytical, Physiological, Pharmacological, Behavioral, and Clinical Aspects (Hardcover, 1984 ed.)
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Neurobiology of the Trace Amines - Analytical, Physiological, Pharmacological, Behavioral, and Clinical Aspects (Hardcover, 1984 ed.)
Series: Polymer Science and Technology Series, 37
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Many of the trace amines-more correctly called biogenic amines-
have been known for decades, but because of their tiny concentra-
tions (0. 01-100 ng/g) in brain, it was only after the development
of sophisticated analytical techniques (such as mass spectrometry)
that they could be identified and quantitated in nervous tissue.
There are now more than 20 of them and most are related to the
catecholamines and 5-hydroxytryptamine both structurally and
metabolically. Their pharmacological and physiological properties
make them prime candidates for a transmitter or neuromodulator role
and many of them elicit profound behavioral syndromes after
injection--one of them, phenylethylamine, has even been referred to
as nature's amphetamine. In the clinical sphere several have been
shown to be involved in: Parkinsonism, schizophrenia, depression,
agoraphobia, aggression, hyperkinesis, migraine, hypertensive
crises, hypertyrosinemia, he- patic encephalopathy, epilepsy, and
cystic fibrosis. Thus the research reported here on these
intriguing "new" substances will be of great interest to
psychiatrists, neurologists, biochemists, pharmacologists,
physiologists, psychologists, behaviorists and indeed to all those
working in the neurosciences and related fields today.
ACKNOWLEDGMENTS This book is based on the proceedings of Trace
Amines and the Neurosciences, a meeting held at the University of
Alberta, Edmonton, July 19-21, 1983. This meeting was organized as
a Satellite Meeting of the Ninth Meeting of the International
Society for Neurochemistry, held in Vancouver, July 10-15, 1983.
International organizers of the satellite meeting were Drs. A. A.
Boulton (Saskatoon), W. G. Dewhurst (Edmonton), G. B. Baker
(Edmonton), and M. Sandler (London).
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