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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Neuropeptide Y Protocols (Paperback, Softcover reprint of the original 1st ed. 2000)
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Neuropeptide Y Protocols (Paperback, Softcover reprint of the original 1st ed. 2000)
Series: Methods in Molecular Biology, 153
Expected to ship within 10 - 15 working days
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The observation that neuropeptide Y (NPY) is the most abundant
peptide present in the mammalian nervous system and the finding
that it elicits the most powerful orexigenic signal have led to
active investigations of the properties of the NPY family of
hormones, including peptide YY (PYY) and pancreatic polypeptide
(PP). Nearly two decades of research have led to the identification
of several NPY receptor subtypes and the development of useful
receptor selective ligands. Moreover, these investigations have
imp- cated NPY in the pathophysiology of a number of diseases,
including feeding disorders, seizures, memory loss, anxiety,
depression, and heart failure. Vigorous efforts are therefore
continuing, not only to understand the bioche- cal aspects of NPY
actions, but also toward developing NPY-based treatments for a
variety of disorders. To facilitate these efforts, it was decided
to produce the first handbook on NPY research techniques as part of
the Methods in Molecular Biology Series. In compiling Neuropeptide
Y Protocols, I have gathered contributions on techniques considered
critical for the advancement of the NPY field from experts in
various disciplines. Each chapter starts with a brief introduction,
with Materials and Methods sections following. The latter sections
are presented in an easy to follow step-by-step format. The last
section of the chapter, Notes, highlights pitfalls and the
maneuvers employed to overcome them. This information, not usually
disseminated in standard research pub- cations, may prove extremely
useful for investigators employing these te- niques in NYP
research.
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