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Books > Medicine > Clinical & internal medicine > Otorhinolaryngology (ENT)
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Clinical Aspects of Microdialysis (Paperback, Softcover reprint of the original 1st ed. 1996)
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Clinical Aspects of Microdialysis (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Acta Neurochirurgica Supplement, 67
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Microdialysis is a minimally invasive method which enables
continuous monitoring of parameters in the extracellular space of
various tissues. It has been investigated in animal models for over
a decade, and many publications have provided insight into its
advantages and disadvantages. However, in spite of its enormous
potential for revealing metabolic processes in normal and
pathological tissue, microdialysis in humans is still in its
infancy. Clinical neurointensive medicine nowadays demands much
more than conventional monitoring methods. As already shown by
jugular bulb measurements of oxygen and lactate, in the future
clinicians will want to have access to continuous neurochemical
information from the patient. This information could be used to
prevent those enigmatic secondary lesions which play such a
negative role in neurointensive medicine, or at least enable
treatment of them at an early stage. The extensive information now
available from the laboratory would help with the interpretation of
clinical analogues. In the University Clinic of Neurosurgery in
Basel we have been involved in the field of micro dialytic
monitoring for several years and have recognised the problems, both
technical and ethical, which are involved in taking the difficult
step from animal experiments to clinical application. In 1994 we
thought that research on clinical microdialysis had reached the
stage which would enable scientists and clinicians to have many
fruitful discussions.
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