Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI. Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments.

d Guide to Diagnosis and Management d Guide to Diagnosis and Management

Medications for epilepsy are mainstays in controlling epileptic seizures. But surgical procedures are another dimension in treatment. Included in this issue will be articles such as: Laser ablation for hypothalamic hamartomas and other epileptic lesions, radiosurgery for epilepsy, minimally invasive neurosurgery using focused MRI guidance, Selective amygdalohippocampectomy, and many more!

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Tourette syndrome (TS) is finally recognized as a common neurodevelopmental disorder, and has gained increasingly high social awareness and scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last decade. Likewise, the way clinicians, teachers, social care workers and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this interesting momentum through a comprehensive and up-to-date overview. Tourette Syndrome covers all of the main aspects related to TS, analyzing the complexity of its clinical presentation, the novel viewpoints of causes and mechanisms, the best way to assess TS patients, and the multifaceted and multidisciplinary treatment options. The multidisciplinary and up-to-date content is the main asset of this volume, which represents a useful source of consultation for a wide audience of professionals, all of whom will have access to what is known so far on TS within their particular area of expertise, at the same time being able to expand and update their knowledge in other areas. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source. Also, questions for future research are clearly presented in the volume, providing a summary of the viewpoint of the contributing authors upon where research on TS should be heading. Finally, clinicians and other health professionals will have access at a glance to the main patients' associations and organizations dedicated to TS worldwide, which can facilitate the direct contact with patients.

THE SUNDAY TIMES NUMBER ONE BESTSELLER 'A vital book about dying. Awe-inspiring and exquisite. Obligatory reading for the living' Nigella Lawson At the age of thirty-six, on the verge of completing a decade's training as a neurosurgeon, Paul Kalanithi was diagnosed with inoperable lung cancer. One day he was a doctor treating the dying, the next he was a patient struggling to live. When Breath Becomes Air chronicles Kalanithi's transformation from a medical student asking what makes a virtuous and meaningful life into a neurosurgeon working in the core of human identity - the brain - and finally into a patient and a new father. What makes life worth living in the face of death? What do you do when when life is catastrophically interrupted? What does it mean to have a child as your own life fades away? Paul Kalanithi died while working on this profoundly moving book, yet his words live on as a guide to us all. When Breath Becomes Air is a life-affirming reflection on facing our mortality and on the relationship between doctor and patient, from a gifted writer who became both. SHORTLISTED FOR THE WELLCOME BOOK PRIZE 2017

Evidence-based medicine is a concept that has come to the fore in the past few years. Clinicians are increasingly encouraged to practise patient management based on available evidence in the scientific literature. For example, new pharmacological therapies are only used when large randomized trials have 'proven' that a particular drug is better than existing ones. This is also the case in surgical specialties, although surgery has traditionally seen a lack of use of this information, with individual surgeon's preferences being most influential in treatment choices. However, more recently, there has been a large expansion of trials and studies aimed at providing surgeons with information to guide their choices using firm evidence. This new edition has been revised and expanded to include new data where relevant, and also features a new chapter on pituitary surgery. Landmark Papers in Neurosurgery, Second Edition, remains a key collection of the most important trials and studies in neurosurgery, allowing the reader to rapidly extract key results, and making it essential reading for all neurosurgeons and trainees in the field.

Neurosurgical Management of Psychiatric Disorders, Part A, Volume 266, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume covering interesting chapters, including Pathophysiology and Animal Models of Psychiatric Disorders, Neuroimaging of Psychiatric Disorders, History of Psychosurgery, Ethics of Psychosurgery, Medicolegal Aspects and Regulatory Issues of Psychosurgery, Psychiatric Mimics of Neurosurgical Disorders, Seizures and Pseudoseizures: The Great Divide, Pitfalls of Psychiatric Patients Selection for Functional Neurosurgery, Modern Surgical Strategies for Management of Psychiatric Disorders, Neuromodulation for Behavioral Disorders, and more.

In this collection of medical tales “reminiscent of Oliver Sacks...the best of medical writing” (Abraham Verghese, author of The Covenant of Water), a neurologist reckons with the stories we tell about our brains, and the stories our brains tell us.

A girl believes she has been struck blind for stealing a kiss. A mother watches helplessly as each of her children is replaced by a changeling. A woman is haunted each month by the same four chords of a single song. In neurology, illness is inextricably linked with narrative, the clues to unraveling these mysteries hidden in both the details of a patient's story and the tells of their body.

Stories are etched into the very structure of our brains, coded so deeply that the impulse for storytelling survives and even surges after the most devastating injuries. But our brains are also porous—the stories they concoct shaped by cultural narratives about bodies and illness that permeate the minds of doctors and patients alike. In the history of medicine, some stories are heard, while others—the narratives of women, of Black and brown people, of displaced people, of disempowered people—are too often dismissed.

In The Mind Electric, neurologist Pria Anand reveals—through case study, history, fable, and memoir—all that the medical establishment has overlooked: the complexity and wonder of brains in health and in extremis, and the vast gray area between sanity and insanity, doctor and patient, and illness and wellness, each separated from the next by the thin veneer of a different story.

Moving from the Boston hospital where she treats her patients, to her childhood years in India, to Isla Providencia in the Caribbean and to the Republic of Guinea in West Africa, she demonstrates again and again the compelling paradox at the heart of neurology: that even the most peculiar symptoms can show us something universal about ourselves as humans.

In this issue of Neurosurgery Clinics, guest editor Dr. Michael T. Lawton brings his considerable expertise to the topic of Update on Open Vascular Surgery. The field of open vascular neurosurgery has undergone significant change as endovascular technologies have advanced and endovascular market share has grown. In this issue, top experts in the field explore various responses to these trends, providing valuable information to neurosurgeons aspiring to stay current with contemporary management of aneurysms, brain arteriovenous malformations, cavernous malformations, and bypass techniques. Contains 15 practice-oriented topics including wide neck and bifurcation aneurysms: balancing open and endovascular therapies; application of big data in vascular neurosurgery; rethinking cerebral bypass surgery; AI, machine learning and cavernous malformations; the transcavernous approach in vascular neurosurgery; and more. Provides in-depth clinical reviews on open vascular surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Drs. Regina Rodman and C. Michael Haben bring their considerable expertise to the topic of Gender Affirmation Surgery in Otolaryngology. Top experts in the field cover key topics such as masculinization laryngoplasty; facial analysis, browlift and brow position; genioplasty for chin reduction; Adam's apple reduction; cheek augmentation; voice tuning refinements with laser; and more. Contains 17 relevant, practice-oriented topics including approach to the transgender patient; impact and expectations of hormone replacement therapy or orchiectomy on the timing of, or necessity for, gender affirmation voice surgery; the role of voice as a source of dysphoria and gender identity; feminization laryngoplasty; voice and speech training for the transgender patient: what the otolaryngologist should know; and more. Provides in-depth clinical reviews on gender affirmation surgery in otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Neurologic Clinics, guest editors Drs. Russell R. Lonser and Daniel K. Resnick bring their considerable expertise to the topic of Neurosurgery for Neurologists. Top experts in the field cover key topics such as indications and advances in surgical epilepsy, critical care management of traumatic brain injury, neurosurgical mimics, surgical neuro-oncology, and more. Contains 16 relevant, practice-oriented topics including degenerative spine disorders and multiple sclerosis; spinal fusion update; intraoperative monitoring for spinal surgery; peripheral nerve injury and compression; diagnosis and treatment of Chiari malformation; and more. Provides in-depth clinical reviews on neurosurgery for neurologists, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Neurosurgical procedures are becoming more common and are taking place in the operating room and in interventional suites. Procedures that used to be performed only at major academic institutions are also being done in small community hospitals, and anesthesiologists in private practice are being asked to care for these patients. In many cases, treatment options are controversial or rapidly evolving. Close cooperation between the anesthesiologist and neurosurgeon is essential to achieve optimal outcomes and early recognition of any adverse events so appropriate therapy can be implemented. Fundamentals of Neuroanesthesia is a comprehensive guide to neuroanesthesia that discusses neurophysiology, neuroanatomy, and neurosurgical procedures and offers practical approaches and solutions to administering neuroanesthesia and providing perioperative care for neurosurgical patients. Chapters emphasize clinical management of neurosurgical problems that may be encountered in community practice as well as major academic medical centers. Highlighted key points, figures, algorithms, and management procedures supplement the text. This book is a must-have volume for general anesthesiologists, anesthesiology fellows, and subspecialists.

In this issue of Neurosurgery Clinics, Guest Editor James A. Stadler brings his considerable expertise to the topic of syndromic neurosurgery. Top experts in the field cover key topics such as Syndromic epilepsy, tumor syndromes, syndromic craniosynostosis, and more. Provides in-depth, clinical reviews on syndromic neurosurgery, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including The history of syndromic neurosurgery; Multidisciplinary evaluation of neurosurgical patients with genetic syndromes; Neurosurgical evaluation and management of children with achondroplasia; Neurosurgical evaluation and management of patients with connective tissue disorders; and more.

This issue of Neurosurgery Clinics, guest edited by Dr. Domagoj Coric, provides an Update on Motion Preservation Technologies. This issue is one of four selected each year by our series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. This issue discusses state-of-the-art indications, technique, devices, complications and evidence basis for motion preserving technologies in the cervical and lumbar spines. Topics covered in this issue will include: Cervical Total Disc Replacement: Indications and Technique, Cervical Total Disc Replacement: Off-label and Expanded Indications, Cervical Total Disc Replacement: FDA-approved Devices, Cervical Total Disc Replacement: Novel Devices, Cervical Spine Surgery: Arthroplasty versus Fusion versus Posterior Foraminotomy, Cervical Total Disc Replacement: Complications and Complication Avoidance, Cervical Total Disc Replacement: Long-term Outcomes, Biomechanics of Cervical Arthroplasty Devices, Adjacent-level Disease following Spinal Arthroplasty, Lumbar Total Disc Replacement: Current Usage, and Posterior Lumbar Facet Replacement and Arthroplasty. Provides in-depth, clinical reviews on the latest updates in Motion Preservation Technologies, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This book addresses wound care in vascular surgery, neurosurgery and lower extremity ulcers, while also providing detailed information on the latest concepts in antimicrobial therapy. The book presents essential content on the assessment, care, measurement and repair of wounds, and describes important scientific aspects as well as current clinical techniques. Due to the various topics covered, the book offers a valuable resource not only for plastic surgeons, but also for neurosurgeons, vascular surgeons and all clinicians who are interested in learning about current antimicrobial agents and their use.

This issue of Neurosurgery Clinics, guest edited by Drs. Edjah Nduom and Jeff Olson, will focus on Metastases to the Central Nervous System. This issue is one of four selected each year by our series consulting editors, Dr. Russell R. Lonser and Dr. Daniel K. Resnick. Topics discussed in this issue will include: Epidemiology of metastatic CNS disease, Initial approach to the patient with a newly diagnosed solitary brain metastasis, Initial approach to the patient with multiple newly diagnosed brain metastases, When to consider a stereotactic biopsy for brain metastases, Techniques for open surgical resection of cerebral metastases, Laser ablation for cerebral metastases, Histopathological features and laboratory markers of common brain metastases, Recurrence vs radiation necrosis - evaluation and treatment, Anti-epileptic drugs for the management of cerebral metastases, Chemotherapy for the management of cerebral metastases, Approach to the management of metastatic leptomeningeal disease, Immune therapy for CNS metastases, Novel therapeutic targets for the treatment of cerebral metastases, Skull base metastases - diagnosis and management, and more.

This book covers the explosion of new information about the relationship between the brain and its blood supply since the first edition was published in 2009. With new knowledge and its impact on clinical care, neurovascular neuropsychology has become a recognized sub-specialty that has been integrated into health care systems in the US and abroad. The second edition brings to this larger audience the latest word on these matters, with new emphasis on women's issues, relevance to the pediatric population, insights from modern imaging, and advances in medical and surgical treatments such as heart transplantation, cardiovascular transarterial therapies, and noninvasive brain stimulation in connection with neurocognitive outcomes.