Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers, and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment, and repair.

A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

A medical degree opens many doors, but how do you decide which is the right one to go through? Whether you are wondering how to choose a career or want to know how to follow a particular path, you'll find the answers in this book. Deciding which medical career to pursue has a huge impact on your future, and yet few doctors or medical students ever receive formal careers advice. Fortunately help is at hand: this book has been fully rewritten to include the latest information on training and career progression, as well as summaries of over 100 different careers open to medical graduates. Whether you aspire to be a general practitioner, medical manager, forensic pathologist or even a brain surgeon, you'll find details on the job, lifestyle, and specific career route. Each career chapter has been written by specialists in their field to give you a unique 'insider's opinion', resulting in the most complete and up to date medical careers guide ever published. Alongside the careers chapters there are new and updated sections on the Foundation Programme, Core Training, Specialty Training, and Academic Training. These describe the major hurdles in each area and how to overcome them. In addition, alternatives and adaptations to formal training are explored, including taking time out, working outside the UK, and working less than full time. From choosing jobs and filling application forms, to interviews and improving your CV, this book covers every aspect in detail.

This book provides a valuable guide to understanding idiopathic intracranial hypertension (IIH), which is a very complex and painful disease. It is a chronic, often disabling condition resulting in headaches, visual loss, and ringing in the ears. This condition was thought to be rare but is becoming much more common, especially as the population becomes more overweight. Patients with this condition often suffer from intractable headaches with poor quality of life. Very few physicians specialize in this condition, and as a result, there is almost no information or resources available to those trying to understand this condition. The text is designed to take very complex neurosurgical anatomy, principles, and treatments and reduce them down into simple principles. The book contains 12 chapters, each organized into distinct sections. All chapters also contain key points from those paragraphs to summarize useful take home messages. Written by an expert specializing in this debilitating condition, Idiopathic Intracranial Hypertension Explained serves as a valuable guide towards understanding and treating IIH. The ultimate goal is to empower patients and families with knowledge about the disease.

'A SUPERB ACHIEVEMENT' IAN MCEWAN * * * * * What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut through the stuff that creates thought, feeling and reason? How do you live with the consequences when it all goes wrong? DO NO HARM offers an unforgettable insight into the highs and lows of a life dedicated to operating on the human brain, in all its exquisite complexity. With astonishing candour and compassion, Henry Marsh reveals the exhilarating drama of surgery, the chaos and confusion of a busy modern hospital, and above all the need for hope when faced with life's most agonising decisions. * * * * * Winner: PEN Ackerley Prize South Bank Sky Arts Award for Literature Shortlisted: Costa Biography Award Duff Cooper Prize Wellcome Book Prize Guardian First Book Award Slightly Foxed Best First Biography Prize Longlisted: Samuel Johnson Prize for Non-Fiction

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Spine Secrets Plus, 3rd Edition, by Dr. Vincent J. Devlin, features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series (R) format gives you the most return for your time - succinct, easy to read, engaging, and highly effective. Fully revised and updated throughout, including protocols and guidelines that are continuously evolving and that increasingly dictate best practices. Expanded PLUS format includes extended coverage, a larger format, colorful visual elements, and larger, detailed images and illustrations to provide an overall enhanced learning experience. Remain at the forefront of the nuances of spine surgery and related specialties with updates on new techniques and technologies, as well as changing treatment options and drug information. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Zero in on key information with bulleted lists, mnemonics, and practical tips from prominent specialists - all providing a concise overview of important, board-relevant content. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

With an emphasis on the "how and why" of contemporary surgery, Operative Techniques in Surgery, Second Edition, features concise, bulleted text, full-color illustrations, and intraoperative photographs to clarify exactly what to look for and how to proceed. Meticulously edited by Drs. Mary T. Hawn, Aurora D. Pryor, Steven J. Hughes, Michael S. Sabel, Kellie R. Brown and Amy J. Goldberg, this comprehensive, two-volume surgical atlas focuses on the steps of each technique, rapidly directing you to the information you need to choose the right approach for each patient, perform it successfully, and achieve the best possible results. Coverage includes open as well as laparoscopic, robotic, endoscopic, and endovascular procedures in gastrointestinal, thoracic, esophageal, colorectal, hepatobiliary, breast, endocrine, dermatologic, vascular, and trauma surgery New, comprehensive section on trauma surgery, helmed by trauma expert Dr. Amy J. Goldberg New section editors for esophageal and foregut surgery and vascular surgery, Dr. Aurora D. Pryor minimally invasive surgery leader and Kellie R. Brown, expert in vascular surgery. New videos, personally selected by contributing authors and editors, accompany numerous chapters throughout the book Extensive updates throughout, including new coverage of the American Board of Surgery's SCORE Curricula for General Surgery and for Complex General Surgical Oncology Each procedure follows the same format: differential diagnosis, patient history and physical findings, imaging and other diagnostic studies, surgical management, techniques, pearls and pitfalls, postoperative care, outcomes, and complications Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This book represents the first interdisciplinary text on the emerging field of rehabilitative surgery, in which state of the art procedures from multiple surgical specialties are combined. It proposes a completely new framework for understanding, coordinating, and providing treatment for paralyzed or severely neurologically impaired patients and explains the potentially critical impact of surgery in creating a new baseline of functional status, thereby improving the patient's daily life. Every major aspect of reconstructive surgical treatment is considered, including anesthesia, orthopedic surgery, plastic surgery, neurosurgery, general surgery, vascular surgery, and otolaryngology. The most up-to-date and evidence-based surgeries are clearly described and evaluated, with coverage of treatment of pressure sores, placement of feeding tubes, and upper extremity interventions to improve function and hygiene. Cutting-edge protocols are presented for the surgical treatment of severe nerve injuries, spinal cord injuries, and stroke or cerebrovascular accidents, and a first description and evaluation of phrenic nerve repair to assist weaning of paralyzed patients from ventilators is provided. Both surgical and nonsurgical readers will find this book to be an ideal guide and reference.

Large intracranial lesions are among the most complex and dangerous lesions encountered by neurosurgeons, and a single neurosurgical approach often does not provide a large or safe enough corridor for effective treatment. A combined approach to these surgeries, incorporating open, endoscopic, vascular and keyhole techniques can be more successful. This comprehensive text describes in detail how to select the most appropriate approaches, as well as how to avoid any complications that may arise. High quality videos of the techniques described are available through an online version on Cambridge Core, accessible via the code printed on the inside of the cover. With over 150 colour images supporting the text, this is a definitive reference for anyone involved in intracranial tumor or vascular surgery.

1 Die Chirurgie des Felsenbeins und der lateralen Schadelbasis.- 1 Unsere Langzeiterfahrungen bei der Behandlung von jugulotympanalen Paragangliomen.- 2 Der Wert der Somatostatinszintigraphie in der Diagnostik der Paragangliome.- 3 Das Felsenbeinkarzinom - eine interdisziplinare Herausforderung.- 4 Unser Konzept beim Karzinom des ausseren Gehoerganges.- 5 Moeglichkeiten und Grenzen der Karotiskanalchirurgie.- 6 Intrakraniell bedrohliche Erkrankungen durch unscheinbare Entzundungen des Mittelohrs.- 7 Der transtemporale Zugang zum Klivus und zur petroklivalen Region Chirurgische Anatomie und klinische Erfahrung.- 8 Topographische Anatomie der Felsenbeinspitze und des Dorello-Kanals.- 9 Differentialdiagnosen von Raumforderungen des inneren Gehoergangs.- 10 Zum Stellenwert der Sakkotomierevision in der Behandlung des Morbus Meniere.- 11 Der subtemporale Zugangsweg - eine gehoererhaltende Alternative beim Felsenbeincholesteatom.- 12 Wie stellt sich die laterale Schadelbasis im Dunnschnittplastinat dar?.- 13 Langerhans-Zellhistiozytose mit Beteiligung des Felsenbeins.- 14 Massive Osteolyse Gorham-Stout des Felsenbeins und des kraniozervikalen UEbergangs.- 15 Falldarstellung: Lymphangiom des Felsenbeins.- 16 Missbildungen der lateralen Schadelbasis.- 2 Die Therapie des Vestibularisschwannoms.- 17 Funktionserhaltende Chirurgie des Akustikusneurinoms - Ergebnisse interdisziplinarer Kooperation.- 18 Hoervermoegen vor, wahrend und nach transtemporaler Akustikusneurinomexstirpation.- 19 Wurzburger Schule der Akustikusneurinomchirurgie Interdisziplinare Chirurgie des Akustikusneurinoms - Wurzburger Konzept aus der Sicht des Otochirurgen.- 20 Zur Wait-and-See-Strategie beim einseitigen Akustikusneurinom.- 21 Die radiochirurgische Therapie des Akustikusneurinoms Technik im internationalen Vergleich.- 22 Rundtischgesprach zur Therapie des Vestibularisschwannoms.- 3 "Multi-information-guided therapy", CAS und neue Technologien in der Schadelbasischirurgie.- 23 3D-Navigation an der frontalen und lateralen Schadelbasis.- 24 Intraoperative Bildgebung und Neuronavigation - Gegenwart und Weiterentwicklung.- 25 Die Kombination der konventionellen CAS mit der intraoperativen Navigation der Laterobasis: enhanced CAS.- 26 Telemedizin in der Chirurgie der lateralen Schadelbasis - Vergleich ISDN, Internet, ATM.- 27 Computerassistierte Chirurgie der lateralen Schadelbasis Aktuelle Moeglichkeiten und zukunftige Entwicklungen.- 28 Variationen des navigationsgestutzten Zugangs zur lateralen Schadelbasis.- 29 Moegliche Fehler bei der Anwendung von CAS-Systemen an der Schadelbasis.- 30 Anwendungsmoeglichkeiten der Telemedizin in der Schadelbasischirurgie.- 31 MRT-Visualisierung der Schadelbasisregion von unfixierten und kurzzeitfixierten Materialien.- 4 Experimentelle und histopathologische Untersuchungen zur Chirurgie der lateralen Schadelbasis.- 32 Tierexperimentelle Untersuchung zur medikamentoesen Therapie der traumatischen Optikusneuropathie.- 33 Molekulargenetische und zellbiologische Untersuchungen am NF2-Gen.- 34 Analyse des adenoidzystischen Karzinomes mittels Laser-Scanning-Zytometrie.- 35 Das maligne fibroese Histiozytom der Kieferhoehle.- 36 Das intratemporale Fazialisneurinom: Diagnostik und Therapie.- 37 Neurobiokompatibilitat von Titan, Gold und Silikon in vitro.- 38 Angiosarkomentstehung in Schwannomen des Nervus vagus.- 39 Minimal-invasiv applizierbare Zell- und Gewebetrager fur die Schadelbasischirurgie.- 40 Dehiszenzen des Paries jugularies und Haufigkeit zusatzlicher Knochenkanale der Fossa jugularis.- 5 Aktuelle Aspekte der Chirurgie der vorderen Schadelbasis.- 41 Neue Aspekte zur Therapie des Lagophthalmus.- 42 Invasive Mukozelen der Stirnhoehle - therapeutisches Vorgehen.- 43 Das Osteosarkom der Schadelbasis.- 44 Dorsale und ventrale kraniozervikale Stabilisierung bei progredienter basilarer Impression nach Densresektion bei PCP.- 45 Optikusdekompression bei bewusstlosen Patienten.- 46 Dislokation des

In "Revision Sinus Surgery" the world’s most prominent rhinologists illustrate their experience in diagnosing and managing recurrent sinus disease and skull base lesions. Starting with preoperative planning and medical management, these challenging cases are well-illustrated with the relevant surgical techniques. This invaluable resource is designed to prevent complications and improve the outcomes of revision sinus surgeries. Both practicing and in-training otolaryngologists can use this comprehensive volume as an all-in-one source for the evaluation and management of recurrent sinus disease and skull base pathology.

Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.

This book follows a context-based approach to management of early-onset scoliosis (EOS) in countries with limited resources in education, finance, and research. Due to the great variety in etiology, onset age, progression rate, and severity associated with EOS, it calls for a unique treatment plan. This book enumerates the optimal provision of surgical and non-surgical services, from education/training of local surgeons, to effective teamwork, to implementing an effective data collection system; helping the surgeon to gain a hands-on experience. It also illustrates the successful execution of deformity correction using real life experiences from countries in Asia, Africa, and Latin America. Key Features Discusses biomedical principles that will help to get universally standard implants that are credible and affordable for countries with limited resources. Specific surgical Guidelines and the ability to develop evidence-based practice for this service would be an interesting read for surgeons working in global organizations as well as to local surgeons. First book to focus on countries with limited resources for the management of early onset scoliosis.

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

This comprehensive and practical book fills the current knowledge gap about the incidence and characteristics of seizures in all kinds of cerebrovascular disorders. Chapters are divided according to the nature of cerebrovascular diseases and highlight incidence, early versus late onset seizure types, pathophysiology, electro-clinical manifestations, treatment and prognosis. Authored by leaders in the field of epilepsy and stroke, Seizures in Cerebrovascular Disorders is an excellent resource for the daily management of patients suffering from this disease overlap.

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

This book, featuring more than 180 high spatial resolution images obtained with state-of-the-art MDCT and MRI scanners, depicts in superb detail the anatomy of the temporal bone, recognized to be one of the most complex anatomic areas. In order to facilitate identification of individual anatomic structures, the images are presented in the same way in which they emanate from contemporary imaging modalities, namely as consecutive submillimeter sections in standardized slice orientations, with all anatomic landmarks labeled. While various previous publications have addressed the topic of temporal bone anatomy, none has presented complete isotropic submillimeter 3D volume datasets of MDCT or MRI examinations. The Temporal Bone MDCT and MRI Anatomy offers radiologists, head and neck surgeons, neurosurgeons, and anatomists a comprehensive guide to temporal bone sectional anatomy that resembles as closely as possible the way in which it is now routinely reviewed, i.e., on the screens of diagnostic workstations or picture archiving and communication systems (PACS).

Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.

This book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.

This volume of Advances and Technical Standards in Neurosurgery covers some important new developments in functional neurosurgery and endovascular therapy. In the Technical Standards section a variety of topics are considered, including optic pathway gliomas, pineal lesions, cavernous sinus meningiomas and the eternal problem of minor and repetitive head injury. Endovascular treatment of a variety of lesions is now common practice and the state of the art in endovascular treatment for acute ischemic stroke is reviewed. An appraisal of the evidence on whether there is a place for microsurgical vascular decompression for essential hypertension raises interesting questions. The volume is completed by contributions on neurosurgical treatment of cluster headaches and occipital nerve stimulation.

This book describes the specific surgical techniques currently employed in patients with intractable epilepsy; it also covers the relevant technical aspects of general neurosurgery. All of the approaches associated with the various foci of epilepsy within the cerebral hemispheres are considered, including temporal and frontal lobectomies and corticectomies, parietal and occipital lobe resections, corpus callosotomy, hemispherectomy, and multiple subpial incisions. In addition, an individual chapter is devoted to electrocortical stimulation and functional localization of the so-called eloquent cortex. The more general topics on which guidance is provided include bipolar coagulation (with coverage of the physical principles, strength of the coagulating current, use of coagulation forceps, the advantages of correct irrigation, and use of cottonoid patties) and all of the measures required during the performance of operations under local anesthesia. The book is designed to meet the need for a practically oriented source of precise information on the operative procedures employed in epilepsy patients and will be of special value for neurosurgical residents and fellows.

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

This book is designed to provide the practicing interventionist with a comprehensive list of procedural reports that covers the vast majority of the currently performed interventional procedures outside the cardiac system. It offers up-to-date explanatory notes, synopsis of the indications, contraindications and potential complications in an organized and practical format that follows the various body systems and progresses from the simple image guided FNA to the most complex procedures and incorporates the current societal guidelines. The book is divided for ease of reference into three main parts: Non vascular, Vascular and Neurovascular interventions. This information is not currently available in any single publication. The text provides residents, fellows as well as staff members with a quick, detailed and user-friendly resource for documentation of image-guided interventional procedures that will facilitate their tasks, improve the standard of documentation and reduce errors. The text can serve as a valuable tool for a quick review prior to a procedure or in preparation for an oral board certifying examination. The entries are vetted by recognized experts in the field of image-guided intervention. Procedural Dictations in Image-Guided Intervention: Non-Vascular, Vascular & Neuro Interventions covers the vast majority of the currently practiced image-guided interventions in the various body systems. This information is supported by up-to-date references and international guidelines. This book is a must-have for residents and fellows undergoing training and all specialists in image-guided intervention.