Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Advances and Technical Standards in Neurosurgery was conceived in 1972byitsfoundingfathersJeanBrihaye,BernardPertuiset,FritzLoew andHugoKrayenbuuhlatacombinedmeetingoftheItalianandGerman NeurosurgicalSocietiesinTaormina. Itwasdesignedtocomplementthe Europeanpost-graduatetrainingsystemforyoungneurosurgeonsandwas ?rst published in 1974 initially through sponsorship by the European AssociationofNeurosurgicalSocieties. Allcontributionshavebeenp- lishedinEnglishtofacilitateinternationalunderstanding. Theambitionofallsuccessiveeditorialboardshasbeentoprovidean opportunityformaturescholarshipandre?ection,notconstrainedbyar- ?ciallimitsonspace. Theseriesprovidesaremarkableaccountofprogress overthepast35years,bothwithregardtoadvances,detaileddescriptions of standard operative procedures and in- depth reviews of established knowledge. Thepresentvolumeisnoexceptionandshouldappealtoboth experiencedneurosurgeonsandyoungneurosurgeonsintrainingalike. TheEditors Contents Listofcontributors...XIII Advances Present and potential future adjuvant issues in high-grade astrocytic glioma 1,2 1 1 2 1 treatment. F. LEFRANC ,M. RYNKOWSKI,O. DEWITTE,andR. KISS, Department ofNeurosurgery,ErasmeUniversityHospital,FreeUniversityofBrussels(U. L. B. ), 2 Brussels,Belgium, LaboratoryofToxicology,InstituteofPharmacy,FreeUniversity ofBrussels(U. L. B. ),Brussels,Belgium Abstract...4 Introduction...5 Naturalresistanceofmigratingmalignantgliomacellstoapoptosis (radiotherapyandchemotherapy)...6 Patternsofcelldeath...8 Autophagy:apotentialTrojanhorseformalignantgliomas...11 Therapeuticbene?tsoftemozolomide...13 Localtherapiesforglioblastomas...15 Ongoingclinicaltrialsforglioblastomas...16 Growthfactorreceptorinhibitors ...17 PI3K=Akt,mTORandNF- Binhibitors...17 Matrixmetalloproteinase(MMP)inhibitors(MMPI)...18 Angiogenesistargeting ...19 Cellularandvaccinationtherapies...20 Genetherapy...20 Reducingmalignantgliomacellmotilityinordertorestore pro-apoptoticdrugsensitivity...20 Thesodiumpumpconstitutesapotentialtargettocombat malignantgliomas...21 Thesodiumpump...22 Cardiotonicsteroids:ligandsofthesodiumpump...24 VIII Contents Thesodiumpumpisinvolvedincancercellproliferation, migrationanddeath...24 Braintumorstemcellsapotentialtargettocombatmalignantgliomas...26 Conclusions...27 References...2 8 Deepbrainstimulationforpsychiatricdisorders-stateoftheart. T. E. SCHLA APFER and B. H. BEWERNICK, Brain Stimulation Group, Department of Psychiatry and Psychotherapy,UniversityHospitalBonn,GermanyandDepartmentsofPsychiatry andMentalHealth,TheJohnsHopkinsUniversity,MD,USA Abstract...37 Introduction...38 Historyofdeepbrainstimulation...39 PrinciplesofDBS...40 NeurobiologyofdepressionandOCD...41 Neurobiologyofdepression...41 NeurobiologyofOCD...42 StudiesofDBSandpsychiatricdisorders...43 Problemsintargetselection...43 Targetsindepression...43 TargetsinOCD ...46 SafetyandadvantagesofDBS...47 EthicalaspectsandstandardsinDBS...51 Ethicalconsiderations...51 ThepathtowardsmandatorystandardsforDBSinpsychiatricdisorders...52 Conclusions...53 ThefutureofDBS...54 References...54 Standards High?owextracranialtointracranialvascularbypassprocedureforgiantan- rysms:indications,surgicaltechnique,complicationsandoutcome. H. C. PATEL and P. J. KIRKPATRICK, Department of Academic Neurosurgery, Addenbrooke's Hospital,UniversityofCambridge,Cambridge,UK Abstract...61 Introduction...62 Surgicaltechnique...67 Cranialexposure...69 Cervicalexposure...70 Saphenousveinexposure...71 Preauriculartunnel...7 2 Contents IX Anastamoses...73 Distalanastamosis...73 Externalcarotidanastamosis...74 Closureandpostoperativecare...77 Discussion...77 Comparisonofoutcomes...77 Choosingthetypeofgraft...78 Longtermpatencyofgrafts...79 Ischaemiccomplications...79 Anticoagulationrelatedmorbidity...81 Conclusion...

This book represents the first interdisciplinary text on the emerging field of rehabilitative surgery, in which state of the art procedures from multiple surgical specialties are combined. It proposes a completely new framework for understanding, coordinating, and providing treatment for paralyzed or severely neurologically impaired patients and explains the potentially critical impact of surgery in creating a new baseline of functional status, thereby improving the patient's daily life. Every major aspect of reconstructive surgical treatment is considered, including anesthesia, orthopedic surgery, plastic surgery, neurosurgery, general surgery, vascular surgery, and otolaryngology. The most up-to-date and evidence-based surgeries are clearly described and evaluated, with coverage of treatment of pressure sores, placement of feeding tubes, and upper extremity interventions to improve function and hygiene. Cutting-edge protocols are presented for the surgical treatment of severe nerve injuries, spinal cord injuries, and stroke or cerebrovascular accidents, and a first description and evaluation of phrenic nerve repair to assist weaning of paralyzed patients from ventilators is provided. Both surgical and nonsurgical readers will find this book to be an ideal guide and reference.

This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such "breakthrough" in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

Implement TMR with Your Patients and Improve Their Quality of Life

Developed by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantages over other neural-machine interfaces for the improved control of artificial limbs. Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs provides a template for the clinical implementation of TMR and a resource for further research in this new area of science.

After describing the basic scientific concepts and key principles underlying TMR, the book presents surgical approaches to transhumeral and shoulder disarticulation amputations. It explores the possible role of TMR in the prevention and treatment of end-neuromas and details the principles of rehabilitation, prosthetic fitting, and occupational therapy for TMR patients. The book also describes transfer sensation and discusses the surgical and functional outcomes of the first several TMR patients. It concludes with emerging research on using TMR to further improve the function and quality of life for people with limb loss.

With contributions from renowned leaders in the field, including Drs. Kuiken and Dumanian, this book is a useful guide to implementing TMR in patients with high-level upper limb amputations. It also supplies the foundation to enable improvements in TMR techniques and advances in prosthetic technology.

Contemporary spinal surgeons, whether orthopedic or neurosurgeons, are increasingly recognizing minimally invasive spine surgery (MISS) as a valuable option for managing advanced degenerative diseases. MISS techniques minimize blood loss and surgical site pain, while speeding recovery. Thus, the combination of MISS with adult spinal deformity was a natural choice. Currently, the techniques, technologies, and education of surgeons have finally reached a point where MISS deformity surgeries are becoming commonplace. Nevertheless, the field is young enough (and still evolving) that no comprehensive texts have addressed the unique challenges it poses for surgeons. This book fills that gap.

Evolved from working with head injured groups at Headway and those attempting to return to work, this is a rich, comprehensive and photocopiable workbook for professionals, carers and clients. It contains over 140 cognitive rehabilitation exercises - tailored for memory, thinking skills, executive functions, awareness and insight, and emotional adjustment. It provides more than 40 information sheets on key problem areas, with questions for the reader, designed to educate and stimulate thinking and discussion. Suitable for both individuals and groups, it includes questionnaires for clients to complete with or without help and quizzes to evaluate and encourage information retention. Primarily for professionals where exercises or handout sheets can be photocopied and used therapeutically, The Brain Injury Workbook can also be used by carers or family members to provide stimulating activities for a head-injured person. In addition, the head-injured person themselves can work through the book on their own.

Kumar and colleagues' Neurocritical Care Management of the Neurosurgical Patient provides the reader with thorough coverage of neuroanatomical structures, operative surgical approaches, anesthetic considerations, as well as the full range of known complications relating to elective and non-elective neurosurgical procedures. Drawing upon the expertise of an interdisciplinary team of physicians from neurosurgery, neurology, anesthesiology, critical care, and nursing backgrounds, the text covers all aspects intensivists need to be aware of in order to provide optimal patient care. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Over 100 world-renowned authors from multispecialty backgrounds (neurosurgeons, neuro-interventionalists, and neurointensivists) and top institutions contribute their unique perspectives to this challenging field. Six sections cover topics such as intraoperative monitoring, craniotomy procedures, neuroanesthesiology principles, spine and endovascular neurosurgery, and additional specialty procedures. Includes 300 tables and boxes, 70 line artworks, and 350 photographic images. Clinical pearls pulled out of the main text offer easy reference.

This new edition has been fully revised to provide spine surgeons with the latest advances in their field. Beginning with an overview of surgical anatomy of the spine, the following chapters describe numerous surgical techniques for each section of the spine – cervical, thoracic, and lumbosacral. The text covers both traditional and new procedures, and includes discussion on recent technologies such as disk arthroplasty and minimally invasive techniques. The final section of this comprehensive volume focuses on associated practices including graft harvesting, discography, and cement augmentation. Authored by renowned experts in the field, this guide is enhanced by clinical photographs and diagrams. A list of ‘key points’ summarises the most important aspects in each chapter. Previous edition (9789350903261) published in 2013. Key points Fully revised, new edition presenting latest advances in spinal surgery Covers techniques for each section of the spine Authored by internationally recognised, US-based experts in the field Previous edition (9789350903261) published in 2013

Tumors involving peripheral nerves may be extremely challenging lesions to diagnose and treat. In order to optimize their management, physicians should have a thorough knowledge of peripheral nerve anatomy and pathology (both gross and microscopic), as well as familiarity with microsurgical techniques and intraoperative neurophysiological recording. This compendium deals with all aspects of tumors affecting peripheral nerves, from diagnosis to treatment; the topics it addresses range from epidemiology, anatomy, physiology, pathology, and clinical diagnosis to electrophysiology, imaging, genetic/cytomolecular aspects. Surgical approaches, biopsies and resection of various benign, malignant and pseudo-tumoral lesions, plexus tumors (both brachial and lumbosacral), and adjunctive treatment modalities and pain-related issues are described in detail. The book is intended not only for neurosurgeons, hand surgeons, plastic and orthopedic surgeons new to the field, but also for seasoned specialists who wish to update their knowledge with new insights based on robust experimental and clinical material. In addition, it will be a helpful tool for general and oncological surgeons who are sometimes faced with the treatment of mass lesions that may be potential nerve tumors, and for all practitioners who are engaged in the arduous struggle to bring relief to patients affected by these lesions.

Most people think that stroke victims end up looking like Frankenstein with a horrible facial expression and erratic movements. But, that is not the way it has to be. Today, it is possible for some stroke victims to make a full recovery. Gerry Purdy knows this because his wife, Alicia - a healthy, beautiful and smart person - suffered a stroke on August 23, 2011 and was able to return to her vivacious self. Our Stroke of Luck portrays the life they had together. Gerry and Alicia had dated in high school and got back together for their 45th high school reunion. Life was good. And then - Bam! - without warning Alicia suffered a stroke. Find out how Alicia's neurosurgeon was able to remove the clot from her brain that caused the stroke. Experience the tense ups and downs of that night-one moment seeming as though she might be paralyzed on her left side for the rest of her life and then the next seeing a flash of hope. Gerry and Alicia were lucky that the radiologist was able to identify the clot in her brain and lucky to get her transferred to the Marcus Stroke Center at Grady Hospital in Atlanta. They were lucky that Dr. Nogueira was able to extract the clot from Alicia's brain. And, finally, they were lucky that she was able to make a full recovery. Truly, this was their stroke of luck.

This new book from leading neurosurgeon and author Gary Kraus is an account of traumatic brain injury (TBI) from the time a brain-injured patient arrives in the emergency department through to the wide range of clinical outcomes of such an injury. Written with the voice of experience, the author examines causation of TBI, the patient’s stay in the neuro-intensive care unit and the many neurological assessments and tests that inform the outcomes that the patient and their families will encounter. A wide range of medical professionals will benefit from Dr Kraus’s acute insights into TBI including Neurosurgical residents, Neurosurgeons with a sub-specialist interest in Neuro-Trauma, Neurologists managing patients with post traumatic brain injury, Neuro-Intensivists, Neuro-Psychologists, Researchers/scientists involved in Clinical trial in traumatic brain injury, and those with a specialist interest in Neuro-rehabilitation.

An easy to follow step-by-step guide to the most useful surgical skills from knot tying to simple procedures. Illustrated with colour photographs and video clips to demonstrate techniques, this book makes these practical skills as clear and easy to follow as possible. Including coverage of surgical instruments, wound management and suturing, and minor surgical procedures, it also explains how to use these essential surgical skills to make the most of a surgical placement. Healthcare students or junior professionals undertaking a placement in surgery or emergency medicine will feel confident and capable, and will be able to take an active role in surgical placements. Learning basic surgical skills is important for such placements, as well as for undertaking exams such as the Membership of the Royal College of Surgeons (MRCS).

A thorough review of the surgical procedures and technologies currently available for the treatment of various movement disorders, this guide illustrates strategies for the management of conditions such as Parkinson's disease, essential tremor, dystonia, Tourette's syndrome, hemifacial spasm, and cerebral palsy-emphasizing surgical indications and outcomes, as well as methods of complication prevention and avoidance.

This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to 'capture' stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that 'doesn't follow the textbook.' In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well.

Get a fair and balanced perspective on schizophrenia!
Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice is a comprehensive overview of schizophrenia and its treatment from a variety of approaches. The book presents a balanced look at the most influential theoretical perspectives based on empirical research, clinical descriptions, and narrative histories. Dr. Glenn Shean, author of "Schizophrenia: An Introduction to Research and Theory," examines neurocognitive and neurodevelopmental models of brain dysfunction, psychodynamic and family factors, up-to-date pharmacological advances, and successful community programs for discharged patients suffering from this debilitating disorder.
Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice presents a comprehensive review of evidence concerning the epidemiology and course and outcome of schizophrenia based on theoretical groupings and levels of analysis. The book examines the evolution of diagnostic criteria and guidelines, as well as stress-vulnerability and diathesis-stress models, providing critical reviews of biological, genetic, cognitive-behavioral, and phenomenological, approach to understanding and treating schizophrenia.
Topics addressed in Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice include: the history of the concept of schizophrenia the writings of Emil Kraepelin and Eugene Bleuler changes in diagnostic guidelines in the last 50 years General System Theory Perspective diagnostic and statistical manuals Schneider's first rank symptoms and much more! Understanding and Treating Schizophrenia: ContemporaryResearch, Theory, and Practice is an essential resource for undergraduate and graduate students working in psychology, psychiatry, nursing, social work, and social policy.

Get a fair and balanced perspective on schizophrenia!
Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice is a comprehensive overview of schizophrenia and its treatment from a variety of approaches. The book presents a balanced look at the most influential theoretical perspectives based on empirical research, clinical descriptions, and narrative histories. Dr. Glenn Shean, author of "Schizophrenia: An Introduction to Research and Theory," examines neurocognitive and neurodevelopmental models of brain dysfunction, psychodynamic and family factors, up-to-date pharmacological advances, and successful community programs for discharged patients suffering from this debilitating disorder.
Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice presents a comprehensive review of evidence concerning the epidemiology and course and outcome of schizophrenia based on theoretical groupings and levels of analysis. The book examines the evolution of diagnostic criteria and guidelines, as well as stress-vulnerability and diathesis-stress models, providing critical reviews of biological, genetic, cognitive-behavioral, and phenomenological, approach to understanding and treating schizophrenia.
Topics addressed in Understanding and Treating Schizophrenia: Contemporary Research, Theory, and Practice include: the history of the concept of schizophrenia the writings of Emil Kraepelin and Eugene Bleuler changes in diagnostic guidelines in the last 50 years General System Theory Perspective diagnostic and statistical manuals Schneider's first rank symptoms and much more! Understanding and Treating Schizophrenia: ContemporaryResearch, Theory, and Practice is an essential resource for undergraduate and graduate students working in psychology, psychiatry, nursing, social work, and social policy.

For the longest time, neuroendovascular procedures have been done through the femoral artery (TFA) located in the thigh and groin region. Over the last decade, interventional cardiologists have pioneered a newer approach: by utilizing the radial artery in the wrist to access the arterial system, a new procedure has been employed: radial access. Numerous studies and randomized controlled trials have demonstrated this to be a safer way of performing endovascular procedures, and a majority of the interventional cardiac procedures are performed via radial access. The neurointerventional community, however, has been slow to adopt this innovation. The radial access innovation is finally making its way to the neurointerventional community. Radial Access for Neurointervention has all the literature supporting illustrating how radial access is useful to the neuro community. Detailed chapters describe the techniques of radial access including positioning the patient on the table, driving the microcatheters intracranially, aneurysms treatment, AVM/AVF embolizations, complications management, and more. Readily enhanced throughout with pictures and movies, this first-of-its-kind book will guide neurointerventionalists to transition their practices to radial first.

This book describes contemporary clinical practice in the application of neurosurgical methods to the treatment of psychiatric disorders. It covers diverse topics such as neuroimaging, ethics and a historical review, Gamma Knife and High Frequency Ultrasound ablation, deep brain electrical stimulation and preoperative evaluation and postoperative follow-up. Its application in Obsessive Compulsive Disorder, Major Depression, Tourette syndrome, Addiction, Anorexia, Aggression and Schizophrenia are discussed in separated chapters. This book presents concise information provided by clinical and academic practitioners and will facilitate the application of neurosurgical treatment techniques to patients.

Perfect for anyone considering or training in this challenging specialty, Principles of Neurological Surgery, 4th Edition, by Drs. Richard G. Ellenbogen, Laligam N. Sekhar, and Neil Kitchen, provides a clear, superbly illustrated introduction to all aspects of neurosurgery-from general principles to specific techniques. Thorough updates from leading authors ensure that you'll stay abreast of the latest advances in every area of neurosurgery, including pre- and post-operative patient care, neuroradiology, pediatric neurosurgery, neurovascular surgery, trauma surgery, spine surgery, oncology, pituitary adenomas, cranial base neurosurgery, image-guided neurosurgery, treatment of pain, epilepsy surgery, and much more. Offers comprehensive coverage without being encyclopedic - just the right amount of information for those in training or who need an introduction to the field. Provides a strong visual understanding of the essentials of neurosurgery with abundant high-quality illustrations, including imaging, pathology, clinical and operative photographs, surgical line drawings, diagrams, tables, and figures. Presents information in an easy-to-understand, well-written manner, helping you quickly grasp the principles and problems of today's neurosurgery. Features new and improved videos, more emphasis on anatomy and radiology, and new evidence and techniques, keeping you up to date with the latest advances in the field. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Operative procedures performed directly on the base of the brain, inner ear, and cranial nerves are inherently delicate undertakings further complicated by the difficulty of achieving easy access to this confined space. Written by pioneers working at one of the world's leading centers for advanced neurosurgery, An Atlas of Skull Base Surgery clearly describes the steps by which each of the key anatomical structures at the skull base and inner ear may be accessed in order to perform advanced surgical interventions.

Featuring over 170 specially commissioned diagrams, and over 100 photographs of MRI, CT, and other imaging modalities, the atlas comprehensively covers a range of surgical approaches. The authors use the detailed supporting artwork to demonstrate the main steps in each procedure and help readers conceptualize the anatomy and surgical trajectory. With extensive accompanying notes on patient assessment and postoperative care, An Atlas of Skull Base Surgery facilitates the complete evaluation and management of patients with skull base lesions in which the clinical presentation or cell type mandates an operative procedure.

This illustrated colour review covers all aspects of neurology and neurosurgery including: dystonia, tremor, akinetic rigid syndrome (Parkinsonian conditions), infectious diseases, headache, brain tumors, demyelinating disease, epilepsy, neuro-ophthalmology, peripheral neuropathy, clinical neurophysiology, pituitary, coma, neurogenetics, surgical technique, hydrocephalus, AVM/aneurysm, pain and trigeminal neuralgia, head injury, spinal injury, stroke and neuroradiology. The editors and contributing authors all specialise in neurology and/or neurosurgery. The book is aimed at professionals in practice and in training, from hospital based doctors preparing for higher qualifications to established physicians in their continuing professional development. The cases are presented randomly, as in real life and, where appropriate, are superbly illustrated.

This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author's 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery.

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.

This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.

New edition of a highly successful illustrated guide to neurology and neurosurgery for medical students and junior doctors. Comprehensive guide to neurology and neurosurgery for medical students and junior doctors - competing books do not cover both areas Graphic approach to the subject - concise text is arranged around clear and memorable line diagrams. Readers find this approach accessible and easy to learn form Clarifies a subject area which students tend to find difficult and forbidding Updated and revised in all areas where there have been developments in understanding of neurological disease and in neurological and neurosurgical management. This revision has also incorporated current guidelines, particularly recommendations from National Institute for Health and Clinical Excellence (NICE).