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Problem Based Neurosurgery is a remarkable fusion of recent advances in neuro-imaging and neurosurgery with modern teaching of integrated system based curricula. It approaches each problem systematically from history, and physical examination to differential diagnosis, investigations and management options. The book captures four decades of advances and experiences in diagnosis and management of patients. The problems upon which the book is based are real patients and cover all aspects of neurosurgical practice with up to date modern images. The blend of new scientific discoveries, modern imaging and the art of smart history and physical examinations underpins the book to improve diagnosis, investigation and the care of neurosurgical patients.The main thrust of this book is that it is based on clinical problems faced by fellows, residents and students, rather than traditional topic based. Problem based learning and management is the modern method of teaching in the new curriculum of teaching neurosurgery. It is a practical handbook that will help students, residents and community doctors alike. There is no similar book on the market that fulfills the objectives of this handbook.

Drs. Michael Sughrue of the University of California San Francisco and Charles Teo of the Centre of Minimally Invasive Neurosurgery in Sydney Australia have teamed up to deliver a current, comprehensive issue on minimally invasive intracranial surgery.? 11 chapters cover all aspects of this type of surgery, including repair techniques, complication avoidance, and special considerations for movement disorders, tumors, vascular lesions and more.

Dr. Paul Klimo, a Neurosurgeon with the Wright-Patterson Medical Center at the Wright-Patterson United States Air Force Base in Ohio guest edits this informative issue on pediatric vascular neurosurgery.? Dr. Klimo and his contributors cover numerous key topics, including normal and abnormal development of the intracranial vascular system, congenital and inherited pediatric neurovascular diseases, diagnosis and management of arteriovenous malformations in children, radiosurgery for pediatric arteriovenous malformations, neurointerventional techniques in children, intracranial cavernous malformations in children, spinal vascular malformations in children, and many more.

A brain-computer interface (BCI) establishes a direct output channel between the human brain and external devices. BCIs infer user intent via direct measures of brain activity and thus enable communication and control without movement. This book, authored by experts in the field, provides an accessible introduction to the neurophysiological and signal-processing background required for BCI, presents state-of-the-art non-invasive and invasive approaches, gives an overview of current hardware and software solutions, and reviews the most interesting as well as new, emerging BCI applications. The book is intended not only for students and young researchers, but also for newcomers and other readers from diverse backgrounds keen to learn about this vital scientific endeavour.

Guest Edited by experts Paul Nyquist, Neeraj Naval, and Rafael Tamargo of Johns Hopkins, this issue covers a wide range of topics related to Aneurysmal Subarachnoid Hemorrhage, including epidemiology, surgical management, endovascular treatment, non-invasive imaging techniques, risk factors and medical management of vasospasm, cerebral salt wasting, outcomes and costs, medical complications, and more.

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

For this issue, Drs. Daniel Lim and Paul Larson at the University of California San Francisco present a collection of papers dedicated to Functional Neurosurgery. They explore topics such as functional neurosurgery orginis of Intraoperative MRI, iMRI safety, anethesia in the iMRI environment, gene therapy, the use of iMRI for cell-based therapy of Parkinson's desease, and more.

Vascular Anatomy: The Head, Neck and Skull Base; Neurovascular Anatomy of the Brain and Skull; Vascular Anatomy of the Spine and Spinal Cord; Intracranial Collateral Anastomoses - Relevance to Endovascular Procedures; CT Imaging, MR Imaging and Ultrasound; Applications to Endovascular Procedures; Techniques and Devices in Neuroendovascular Procedures; Percutaneous Vertebroplasty; Inferior Petrosal Sinus Sampling in the Diagnosis of Sellar Neuropathology; Physiological Testing; Balloon Occlusion Testing, and WADA Testing in Neuroendovascular Procedures

This volume of Advances and Technical Standards in Neurosurgery covers some important new developments in functional neurosurgery and endovascular therapy. In the Technical Standards section a variety of topics are considered, including optic pathway gliomas, pineal lesions, cavernous sinus meningiomas and the eternal problem of minor and repetitive head injury. Endovascular treatment of a variety of lesions is now common practice and the state of the art in endovascular treatment for acute ischemic stroke is reviewed. An appraisal of the evidence on whether there is a place for microsurgical vascular decompression for essential hypertension raises interesting questions. The volume is completed by contributions on neurosurgical treatment of cluster headaches and occipital nerve stimulation.

For this issue, Dr. Michael Lim of Johns Hopkins and Dr. Isaac Yang of UCSF team up to deliver a packed issue on the latest developments in Immunotherapy.? The issue covers hot topics such as immunostimulants, Passive Antibody Mediated Immunotherapy, Clinical Applications of A Peptide Based Vaccine, Challenges for Clinical Design of Immunotherapy Trials, The EGFRv3 Peptide Vaccine, Stem Cell Therapy and Dendritic Cell Vaccines, Dendritic Glioma Fusion Vaccine, Adoptive Cellular Immunotherapy, Virus Mediated Immunotherapy, and so much more.

This issue is the last of a two-part series dedicated to Neuroendovasular Management and Guest Edited by Robert Rosenwasser and Pascal Jabbour of Jefferson. Part two covers topics such as Neuroendovascular Management of Carotid Cavernous Fistulae, Endovascular Management of Intracranial Aneurysms, Neuroendovascular Management of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage, Neuroendovascular Management of Acute Ischemic Stroke, and many more.

This book focuses on the exciting recent progress in restorative neurology and neuroscience. The book includes chapters on major neurodegenerative disorders of the brain and the visual system, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, macular degeneration, retinitis pigmentosa, glaucoma, spinal cord trauma, and multiple sclerosis. The primary goal of the book is to give an overview of new developments in translational research and in potential therapeutic strategies, including stem cell therapy, immunotherapy, gene therapy, pharmacotherapy, neuroprostheses and deep brain stimulation.
* Provides the reader with a unique overview over all aspects of new advances in the therapy of neurological and psychiatric disorders
* Covers all levels of biological organization including novel molecular and cellular targets, electrophysiological, anatomical and behavioural substrates of neurodegeneration and the application of whole brain in vivo imaging
* Broad focus with contributions by the top scientists worldwide in the respective disciplines

The severe spondylolisthesis/spondyloptosis is still a controverse chapter in spine surgery. This book discusses the state of the art and defines therapeutic strategies. The contributing authors are well-known specialists in the field.

This comprehensive and practical book fills the current knowledge gap about the incidence and characteristics of seizures in all kinds of cerebrovascular disorders. Chapters are divided according to the nature of cerebrovascular diseases and highlight incidence, early versus late onset seizure types, pathophysiology, electro-clinical manifestations, treatment and prognosis. Authored by leaders in the field of epilepsy and stroke, Seizures in Cerebrovascular Disorders is an excellent resource for the daily management of patients suffering from this disease overlap.

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Indispensable for both the trainee and experienced professional, this is the only truly comprehensive account of the major role of the neurosurgeon in the diagnosis and treatment of chronic pain. The elite panel of contributors were chosen due to their expertise and international reputations. The result of their achievement covers the whole spectrum from criteria for patient selection and the details of operative techniques, to the risks, complications, and expected outcomes for a wide variety of anatomic, ablative, and augmentative neurosurgical procedures in treating chronic, intractable pain. The neurosurgeon will find here chapters on the latest neuroaugmentative advances utilizing electrical stimulation and implantable drug infusion systems as well as a useful section providing algorithms and guidelines for the evaluation and treatment of specific pain syndromes. Over 100 photographs and exquisite line drawings - many specifically commissioned for this book - enhance the text. Invaluable for acquiring the critical judgement and clinical skills necessary to apply the procedures involved.

Discover strategies to enhance quality of life and promote social and community participation for people with MS! Occupational Therapy Practice and Research with Persons with Multiple Sclerosis will familiarize you with the complex issues experienced by people who have multiple sclerosis, suggesting ways to enhance your practice or research with this population. This vital resource fills a void in the scarce literature on occupational therapy and multiple sclerosis, providing you with a unique single-source reference on the subject. This book compiles the work and contributions of experts from Europe, Australia, Canada, and the United Statesfrom a variety of fields, including occupational therapy, medicine, physical therapy, and psychology. This thought-provoking book offers new perspectives on potential assessment and intervention ideas and provides information that could be used for broader program planning. This extensive resource will give you a deeper appreciation of the MS disease process and its influence on everyday living for persons with MS and their families. In this collection, you will learn more about: the health-related service needs of older adults with MS the range of fatigue assessment tools that are available for clinical and research applications the effect of wheelchair use on quality of life the implications of tremor on everyday activities the development and use of Lifestyle Management Programs (c) coping processes used by women with MS as they age the symptom and functional limitation profiles experienced by people with MS that lead to referrals to occupational therapy Occupational Therapy Practice and Research with Persons with Multiple Sclerosis contains charts, figures, graphs, and bibliographies to augment the research and studies found in this book. Also provided are contributions by Dr. Nicholas G. LaRoccaa well-known MS researcherand Dr. Carol A. Gaetjensan educator with MS. Occupational therapy students, clinicians, and researchers working with individuals and families who are affected by MS will find this book an important resource in their profession.

Founded by four Swiss surgeons in 1958, AO Spine is a premier knowledge provider in spine surgery and at the forefront of education and research. Endorsed by AO Spine, this book is a comprehensive guide to the management of spinal disorders. Beginning with a general overview of the spine and its physiology and biomechanics, the next section extensively covers the paediatric spine and associated disorders. The following sections discuss conditions found in the different anatomical sections of the spine - cervical, thoracic and lumbosacral - and their history, physical examination, diagnosis and surgical and non-operative management techniques. The final part of the book explores future trends in spine surgery. Authored by leading US-based neuro and orthopaedic surgeons, this textbook is highly illustrated with more than 650 surgical images, diagrams and tables. Key points Comprehensive guide to surgical and non-operative management of spinal disorders Endorsed by AO Spine committee Covers diagnosis and treatment of numerous conditions in each section of the spine Highly experienced and renowned, US-based author team

State-of-the-art Wellknown experts Collection of papers on one topic The contributions in this volume cover recent advances and changing concepts on diagnosis and treatment of resistant epilepsy in children. Topics treated are new insights on mechanisms of epileptogenesis in developing brain, multimodality imaging in pediatric intractable epilepsy, pediatric intractable epilepsy syndromes, pediatric temporal lobe epilepsy surgery, critical review of palliative surgical techniques for intractable epilepsy, treatment modalities for intractable epilepsy in hypothalamic hemartomas, contemporary management of epilepsy in tuberous sclerosis.

This book on spinal restabilization techniques is an anatomical, biomechanical, clinical, radiological, and surgical overview of the diagnostic methods and newest treatment options for use in patients presenting with degenerative disc disease associated with spinal instability. Edited by a Neurosurgeon and a Neuroradiologist with extensive experience in these areas, it covers the most current information in the field of modern spinal corrective surgery. The varied therapeutic options are presented by many of the primary inventors and first users of the wide array of newly developed and individually unique intersegmental stabilization devices, interbody disc fusion appliances and intervertebral disc replacement implants. This international collection of chapters is intended to be of interest not only to spine surgeons, but also to any physician involved in the diagnosis and treatment of degenerative disc disease and spinal instability that is resistant to conservative management.

Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. The immense therapeutic potential is highlighted which arises from the close collaboration of biomedical scientists and biotechnological engineers in this area and signifies the transition from the conventional "resective" surgery to functional neuroprosthetic surgery (Vol. I) and neural networks surgery (Vol. II) which uses neuro-engineering to improve impaired neural function.

Volume I describes techniques and procedures applied in internal contact with non-neural tissues surrounding the nervous system (dura or cerebrospinal fluid), as in the case of epidural stimulation for pain, etc. or intrathecal drug application for the treatment of spasticity and pain. There is also a special section on non-invasive functional neuroprosthetic systems, which are usually applied by transcutaneous contact with the nervous system.