Targeted at clinicians and residents, this series has already become a classic, with one volume published each year. The Advances section presents fields of neurosurgery and related areas in which important recent progress has been made. The Technical Standards section features detailed descriptions of standard procedures to assist young neurosurgeons in their post-graduate training. The contributions have been written by experienced clinicians and are reviewed by all members of the editorial board.

Endovascular Neurosurgery represents a unique collaboration between contributors from a number of specialties, all of whom are concerned with the management of cerebrovascular disease. This provides a balanced account of the efficacy of interventional endovascular techniques in this group of conditions. As a result, Endovascular Neurosurgery will prove an invaluable account of a relatively new specialty and will be essential reading for neurosurgeons, neurologists, neuroradiologists, neurophysiologists and neuroanaesthetists.

Critical care medicine comprises the observation, diagnosis, treatment, and rehabilitation of patients with overt or potential failure of vital functions. Unlike other, bulkier reference texts, Handbook of Acute Critical Care Neurology focuses on one topic for quick and easy use on the job. Written by a highly respected expert in the field, this book will be extremely helpful for the practioner.

Lumbar spine or back pain is one of the most important problems in orthopedics and neurosurgery today. Two key ways of treating this malady, lumbar fusion and stabilization, are critically discussed in the forty-three papers in this volume. They represent the best of the contributions to the 5th ICLFS, carefully selected and edited to give a good overview of recent knowledge and the state of the art.

This book covers the explosion of new information about the relationship between the brain and its blood supply since the first edition was published in 2009. With new knowledge and its impact on clinical care, neurovascular neuropsychology has become a recognized sub-specialty that has been integrated into health care systems in the US and abroad. The second edition brings to this larger audience the latest word on these matters, with new emphasis on women's issues, relevance to the pediatric population, insights from modern imaging, and advances in medical and surgical treatments such as heart transplantation, cardiovascular transarterial therapies, and noninvasive brain stimulation in connection with neurocognitive outcomes.

This new edition presents an authoritative account of the current state of brain biomechanics research for engineers, scientists and medical professionals. Since the first edition in 2011, this topic has unquestionably entered into the mainstream of biomechanical research. The book brings together leading scientists in the diverse fields of anatomy, neuroimaging, image-guided neurosurgery, brain injury, solid and fluid mechanics, mathematical modelling and computer simulation to paint an inclusive picture of the rapidly evolving field. Covering topics from brain anatomy and imaging to sophisticated methods of modeling brain injury and neurosurgery (including the most recent applications of biomechanics to treat epilepsy), to the cutting edge methods in analyzing cerebrospinal fluid and blood flow, this book is the comprehensive reference in the field. Experienced researchers as well as students will find this book useful.

Peripheral nerves are biologic wires that convey the desire for motion from brain to muscle, and the experience of touch from skin to brain. When a nerve is cut, the individual fibers, or axons, must regenerate from the site of injury to reconnect with their skin and muscle targets. Nerve regeneration is a process of bewildering complexity that requires the coordinated action of multiple biologic systems. Gene expression within the neuron is altered to support axon growth, regenerating axons must cross the complex environment of the nerve injury and enter pathways that lead to functionally appropriate end organs, Wallerian degeneration clears these pathways of axon debris, and Schwann cells in the distal nerve must produce growth factors to support regeneration. In spite of this complexity, the surgical repair of transected nerve remains a mechanical process that has changed little in the last century, and that restores normal function to only 10% of adults with nerve injuries. Improving the outcome of nerve repair will require close cooperation between surgeon and scientist. Skyrocketing clinical demands on the surgeon and the rapidly increasing sophistication of neuroscience have interacted to form two distinct cultures. Nerve Repair bridges these cultures by providing a translational review of the clinical and basic science relevant to nerve repair. It provides the clinician with an understanding of pertinent research, and the basic scientist with an overview of the clinical manifestations of nerve injury and regeneration. It is also grounded in the history of peripheral nerve surgery and biology so that modern concepts can be understood in the context of their origins.

This book describes and illustrates an approach to surgery for spinal cord tumors that is based on a refined concept of anatomic compartmentalization. The aim of this approach is to enable maximum preservation of spinal cord function through confinement of the surgical work to the involved compartment or compartments. Importantly, this involvement differs according to tumor type, and the classification favored by the author takes this fully into account. After introductory chapters on epidemiology and pathology, the anatomy of the spinal cord relevant to surgery for spinal cord tumors is discussed in detail and the proposed classification is clearly explained. The surgical approach to each of the identified anatomic compartments is then described, with attention to the roles of intraoperative mapping techniques, diffusion tensor imaging, and electrophysiologic studies in ensuring that spinal cord functions are spared. Examples of the author's experience when applying the proposed approach are presented. The book is meant for neurosurgeons at all levels of experience.

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair.

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). It regulates normal CNS function, is a major participant in pathology, and serves learning, memory, and higher cognitive functions. The 12 chapters of this book provide the first comprehensive coverage of all the major features of glutamate as excitatory neurotransmitter. The book begins with a valuable historical backdrop. Building from a chapter on the common structure of glutamate receptors, several others cover the major ionotropic receptors, their structure, function, and pharmacology. A follow-up chapter discusses the metabotropic receptors that are directly coupled to second messenger metabolism. A central theme of the book is the capacity of the excitatory amino acid system to contribute to the diverse array of signaling systems in the CNS as a direct result of the large assortment of receptors (including, for the ionotropic receptors, various subunits) the combination of which determine distinct functional properties. A recent development in the field discussed in several chapters is the biochemical characterization of a supermolecular protein complex, the post-synaptic density, that makes the unique structure of excitatory synapses. This complex subserves the experience-dependent modulation of synaptic strength and synaptic plasticity, and gives the synapse the capacity to change dynamically in both structure and receptor composition. Drawing on the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation of excitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Alzheimer's disease and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology and new therapeutic strategies. This book will be invaluable for neuroscientists, pharmacologists, neurologists, and psychiatrists, and for their students and trainees.

Unique in the field, Comparative Management of Spine Pathology presents commonly encountered spinal cases with side-by-side, case-by-case comparisons that clearly show how various experts would handle the same case. This second volume in the Neurosurgery: Case Management Comparison Series offers multiple opinions from international experts in both neurosurgery and orthopaedics, each of whom explains their preferred approach and management style for the same case. This format allows for quick and helpful comparisons of different ways to approach a lesion, advantages and disadvantages of each approach, and what each expert is looking for in how they would manage a particular case. Offers 4 expert opinions on each case in a templated format designed to help you quickly make side-by-side comparisons-an ideal learning tool for both trainee and practicing neurosurgeons and orthopaedic surgeons for board review and case preparation. Helps you easily grasp different approaches to spine management with different expert approaches to the same case and summaries from the editors on the advantages and disadvantages to each approach. Features a wide variety of management decisions, from preoperative studies to surgical approach, surgical adjuncts, and postoperative care, from experts in the field who specialize in different aspects of spine surgery. Presents 70 cases in the areas of degenerative spine, traumatic spine, spinal deformity, spinal oncology, and miscellaneous topics such as epidural abscess, osteomyelitis, and post-instrumentation infection. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text and figures from the book on a variety of devices.

Advice for the preparation and execution of clinical and viva components of the Neurosurgical Examinations Comprehensive relevant examination scenarios Key steps in performing the neurological examination Salient points of scientific examination topics

The Musician's Hand - A Clinical Guide was the first book to focus on the specialised topic of the upper limb and hand in musicians: the conditions they suffer, the modified assessment and treatment they require and the importance of prevention. Since its publication in 1998, scientific and clinical progress has been made in all these areas. The second edition of The Musician's Hand has been completely revised under the editorship of hand surgeon Ian Winspur to reflect this expansion in our knowledge. The book opens with introductory chapters describing the principles of hand and arm pain as it is experienced by musicians, and summarising the problems associated with playing various instruments (woodwind, violin, piano, etc). Subsequent chapters cover the specific disorders seen in musicians, (Dupuytren's, nerve compression syndromes, etc) describing the therapeutic solutions to each one and highlighting the key prevention strategies available. Closing chapters focus on related topics such as performance psychology and pharmacotherapy. Featuring contributions from world renowned performers such as Imogen Cooper and global experts in the field, The Musician's Hand, Second Edition provides essential insight to upper limb problems in musicians, not only for surgeons, doctors and therapists, but for all students and teachers of performing arts medicine and to musicians themselves.

This new book from leading neurosurgeon and author Gary Kraus is an account of traumatic brain injury (TBI) from the time a brain-injured patient arrives in the emergency department through to the wide range of clinical outcomes of such an injury. Written with the voice of experience, the author examines causation of TBI, the patient’s stay in the neuro-intensive care unit and the many neurological assessments and tests that inform the outcomes that the patient and their families will encounter. A wide range of medical professionals will benefit from Dr Kraus’s acute insights into TBI including Neurosurgical residents, Neurosurgeons with a sub-specialist interest in Neuro-Trauma, Neurologists managing patients with post traumatic brain injury, Neuro-Intensivists, Neuro-Psychologists, Researchers/scientists involved in Clinical trial in traumatic brain injury, and those with a specialist interest in Neuro-rehabilitation.

This book integrates neuroscience research on neuroplasticity with clinical investigation of reorganization of function after brain injury, especially from the perspective of eventually translating the findings to rehabilitation. Historical foundationw in neuroplasticity research are presented to provide a perspective for recent findings. Leading investigators synthesize their work with research from other laboratories to provide a current update on neuroanatomic features which enhance enuroplasticity and provide a substrate for reorginaization of function. The capacity for recovery from brain injury associated with focal lesions as compared to diffuse cerebral insult is discussed. Interventions such as environmental enhancement and drugs to enhance reorganizatioin of function after brain injury have been studied in animalmodels and in human studies. Methodologies to study neurophysiological measures, trancranial magnetic stimulation, and computational modeling. Implications of neuroplasticity research for innovations in rehabilitation of persons with brain injury are critically reviewed.

This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author's 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery.

In this collection of medical tales “reminiscent of Oliver Sacks...the best of medical writing” (Abraham Verghese, author of The Covenant of Water), a neurologist reckons with the stories we tell about our brains, and the stories our brains tell us.

A girl believes she has been struck blind for stealing a kiss. A mother watches helplessly as each of her children is replaced by a changeling. A woman is haunted each month by the same four chords of a single song. In neurology, illness is inextricably linked with narrative, the clues to unraveling these mysteries hidden in both the details of a patient's story and the tells of their body.

Stories are etched into the very structure of our brains, coded so deeply that the impulse for storytelling survives and even surges after the most devastating injuries. But our brains are also porous—the stories they concoct shaped by cultural narratives about bodies and illness that permeate the minds of doctors and patients alike. In the history of medicine, some stories are heard, while others—the narratives of women, of Black and brown people, of displaced people, of disempowered people—are too often dismissed.

In The Mind Electric, neurologist Pria Anand reveals—through case study, history, fable, and memoir—all that the medical establishment has overlooked: the complexity and wonder of brains in health and in extremis, and the vast gray area between sanity and insanity, doctor and patient, and illness and wellness, each separated from the next by the thin veneer of a different story.

Moving from the Boston hospital where she treats her patients, to her childhood years in India, to Isla Providencia in the Caribbean and to the Republic of Guinea in West Africa, she demonstrates again and again the compelling paradox at the heart of neurology: that even the most peculiar symptoms can show us something universal about ourselves as humans.

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury.

As an addition to the European postgraduate training system for young neurosurgeons, we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo Krayenbuhl. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have been associated throughout with this senes. The fact that the English language is now the international medium for communication at European scientific conferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contri butions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publication of any volume for scrutiny and suggestions for revision. Our series is not intended to compete with the publications of original scientific papers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fields and constitute the first part of each volume.

The international symposium "Syringomyelia 2000" in Kobe, Japan, brought together experts in neurosurgery, neurology, and neuropathology. The decade leading up to this event saw remarkable developments in surgery and imaging technology. The symposium was thus an opportunity for researchers and clinicians to enhance and broaden the scope of their knowledge and to become more aware of work being done in complementary fields. With its collection of papers presented at the Kobe conference, this volume contains a thorough and comprehensive description of syringomyelia - its classification, pathology, and pathophysiology; experimental studies; and its association with abnormalities of the craniocervical junction, Chari II malformation, tethered cord, and other disorders. This compilation provides valuable state-of-the-art information for professionals in the fields of neurosurgery, neurology, and neuropathology and for all others concerned with syringomelia.

This is the second in a sesries of books dealing with the enormous clinical problem of spinal cord dysfunction. Volume I discussed assessment; this book focuses on intervention. There are three main approaches to the restoration of function after damage to the spinal cord: the prevention of seconday pathological events; the identification of impaired or absent functions in nerve cells and processes that survive the initial injury; and restoration of severed neuronal connections. This book addresses the first two of these approaches. It contains a discussion of the arguments about early decompression of the spinal cord following injury, therapy of acute spinal injury, and the effects of early treatment and local cooling on spinal cord blood flow. The management of specific problems associated with spinal cord dysfunction is addressed; these problems include cardiovascular abnormalities due to autonomic dysfunction, bladder control, pain, and sexual function. Current procedures of rehabilitation (particularly the management of chronic problems and the treatment of complications) are summarized, and ideas on motor control and learning are discussed.

The latest in this already classic series presents recent progress and detailed descriptions of standard procedures, to assist young neurosurgeons in their post-graduate training. With contributions from experienced European and American clinicians.

Moyamoya disease (MMD) was first reported as a new entity among vascular disorders in 1957. Named for the abnormal vascular networks found around the occluded distal internal carotid artery, it is the most common pediatric cerebrovascular disease in East Asia. In recent years large amounts of data on MMD have been collected and important investigations have been carried out in Japan and Korea, even as the pathophysiology of the disease remains to be discovered. This monograph covers a diversity of topics and presents a systematic compilation of the data and current status of MMD in clinical practice and basic research. With contributions by more than 70 authors, the book includes sections on genetics, computational analysis of hemodynamic shear stress, new imaging techniques, and endovascular treatment of MMD, along with practical applications and future directions for gene and stem cell therapies. For neurosurgeons as well as neurologists and pediatricians, this volume will help lead to more efficient and informed management of MMD.