Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.

Wireless Cortical Implantable Systems examines the design for data acquisition and transmission in cortical implants. The first part of the book covers existing system level cortical implants, as well as future devices. The authors discuss the major constraints in terms of microelectronic integrations are presented. The second part of the book focuses on system-level as well as circuit and system level solutions to the development of ultra low-power and low-noise microelectronics for cortical implants. Existing solutions are presented and novel methods and solutions proposed. The third part of the book focuses on the usage of digital impulse radio ultra wide band transmission as an efficient method to transmit cortically neural recorded data at high data rate to the outside world. Original architectural and circuit and system solutions are discussed.

During the 1940s and 1950s, tens of thousands of Americans underwent some form of psychosurgery; that is, their brains were operated upon for the putative purpose of treating mental illness. From today's perspective, such medical practices appear foolhardy at best, perhaps even barbaric; most commentators thus have seen in the story of lobotomy an important warning about the kinds of hazards that society will face whenever incompetent or malicious physicians are allowed to overstep the boundaries of valid medical science. Last Resort challenges the previously accepted psychosurgery story and raises new questions about what we should consider its important lessons.

"Rapid Neurology and Neurosurgery" is a must for all medical students and junior doctors - it is a quick and easy on-the-ward or clinic reference and the perfect revision tool for those approaching finals, undergraduate neurology and neurosurgery examinations, and the Membership of Royal College of Surgeons (MRCS) examinations.

It provides a concise, structured approach to neurology and neurosurgery learning, covering key facts in a simple and memorable way: Part I - The Basics - features the basic principles and facts essential for a good understanding of neurology and neurosurgery and includes sections on relevant neuroanatomy; neurological history and examination; and investigations including neurophysiology and neuroradiology. MRI and CT scans are included throughout the text.Part II - Complaints: face to face with the patient - features OSCE-style and the viva-voce examination preparation and has chapters on presenting complaints with relevant and selected questions to ask for establishing the differential diagnoses (presented in a table) with basic investigations and management.Part III - Conditions: applying the basics - presents important clinical conditions with sections on definition; epidemiology; aetiology; associations/risk factors; pathology; history; examination; investigations; management; complications; prognosis and a list of differential diagnoses usually in a table with general clinical information and distinguishing information to exclude the alternative diagnoses.

Each chapter also includes key points to remember and highlights key facts.

"Rapid Neurology and Neurosurgery" contains only the essential, core, and relevant facts in a concise, pocket-sized, 'rapid' refresher providing a thorough foundation of neurology and neurosurgery knowledge allowing you to excel in the examinations.

As an addition to the European postgraduate training system for young neurosurgeons, we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo Krayenbuhl. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have been associated throughout with this senes. The fact that the English language is now the international medium for communication at European scientificconferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contri butions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publication of any volume for scrutiny and suggestions for revision. Our series is not intended to compete with the publications of original scientificpapers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fieldsand constitute the first part of each volume.

This dedicated volume in the series Advances and Technical Standards in Neurosurgery (ATSN) provides a comprehensive approach to diseases of the craniovertebral junction (CVJ) and their management based on the multidisciplinary cooperation of neurosurgeons, anatomists, neuroradiologists, and neuroanesthesiologists. The contributing authors represent the most renowned clinical and surgical experts from Europe and beyond. The main topics highlighted are embryology, normal and abnormal development of the CVJ, including the related vessels, modern radiological contributions to diagnosis, genetic and metabolic factors which may impact on the surgical strategies, the opportunities offered by traditional operative techniques, and the recently introduced minimally invasive and endoscopic surgical modalities. Special emphasis is also placed on the evolution of the principles of surgical treatment as matured during the past decade by experiences in the still open field of pediatric neurosurgery."

Tumor Neurosurgery provides information on the basic knowledge and clinical management required for optimal care of neurooncology patients. Providing an up-to-date synopsis of the field of tumor neurosurgery, the book covers the most common sites and tumor pathologies encountered by neurosurgeons. The chapters are organized under broad topics, including investigative studies, perioperative care and the role of newer techniques. The clinical management of CNS tumors in adults and children is described, including spinal tumors, both intradural and extradural. This book provides coverage of relevant topics in the field of tumor neurosurgery, for residents and registrars in training, and for recent graduates of training programs.

Ronald Brisman, M.D. This book will discuss three areas where the The multiplicity of procedures with varying neurosurgeon may provide an important degrees of risks and benefits sometimes re contribution to the relief of intractable pain: quires a sequential approach, but always an trigeminal and other facial neuralgias, chronic individual one, matching an appropriate treat noncancer pain, and cancer pain. By one ment plan or procedure for a particular patient intervention, the neurosurgeon often may pro at a specific time in his or her illness. vide long-lasting pain relief. New techniques, The neurosurgical chapters in this book which have developed since the 1970s and represent my experience with several hundred continue to evolve, dominate the neurosur patients during a 12-year period from 1975 gical armamentarium because they are not only through 1987. I have relied heavily on the effective, but safe. These include percutaneous works of others, which have been quoted from radio frequency electrocoagulation for trigem the neurosurgical literature, but this book is inal neuralgia, spinal stimulation for chronic not meant to be encyclopedic. noncancer pain, and intraspinal morphine in At least as important as knowing when to fusion for cancer pain. operate is knowing when not to do so, and this Sometimes a procedure relieves pain but the is particularly true of the treatment of pain. pain recurs; it may be necessary to repeat the Most patients with pain do not require neuro procedure, which in the case of radiofrequency surgical intervention."

As the benefits of surgical robotic systems in spine surgery become more widely known, spine procedures that utilize these technologies are expected to greatly increase over the next decade. Robotic and Navigated Spine Surgery: Surgical Techniques and Advancements provides up-to-date, authoritative clinical guidance in this dynamic area for surgeons who are already using these innovative methods, as well as for those exploring the field. In a single, convenient source, this title comprehensively summarizes clinical studies, advancements, and expert recommendations regarding today's robotic and navigated spine surgery. Covers the recent advancements and impact that popular neuronavigation devices and surgical robots have had on the surgical management of the spine, including clinical studies, technical guides, review papers, and expert recommendations. Discusses devices that today's surgeons are most likely to use, such as navigation devices, robotics, augmented reality, and virtual reality systems. Includes focused content on complex spine surgeries, where navigation and robotic devices can have the most significant impact. Features procedural images including radiographs, surgical photos, and equipment photos for visual guidance. Contains chapters on navigation in occipital and cervical spine surgery, spinal trauma and navigation, navigated and robotic-assisted deformity correction, cost-effectiveness of robotic and navigation systems, virtual reality and augmented reality in spine surgery, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Following recent developments in hypofractionated stereotactic radiation therapy (SRT) for brain and spine tumors, this new edition offers a fully updated and comprehensive "how-to" guidance on hypofractionated SRT for brain and spine metastases, glioma, benign tumors, and other tumor types. Presenting the state of the art of the technology and practice, this book: * Discusses the pros and cons of hypofractionated SRT compared to single-fraction radiosurgery, providing a deeper understanding of radiosurgery and radiobiology * Explains the toxicity and adverse effects of hypofractionated SRT including the dosage of 24 Gy in two spine SBRT fractionation schemes, aiding practitioners in communicating the risks and benefits of treatment and in obtaining consent from their patients * Outlines the current standards for safe practice, including checklists for implementation * Explores new technologies for brain and spine tumors including LITT, MR-guided focused ultrasound, and Zap technology, with chapters authored by well-recognized experts in the radiation, oncology, and neurosurgery communities; this book delivers a level of technological and clinical detail not available in journal papers This book is suitable for radiation oncologists, neurosurgeons, and medical physicists who specialize in brain and/or spine radiosurgery or want to start a program and need a comprehensive reference with key checklists for practice.

This issue of Neurosurgery Clinics, guest edited by Dr. Michael A. Vogelbaum, is devoted to Glioblastoma, Part I: Surgical Management and Adjuncts. This is one of four issues selected each year by the series Consulting Editors, Russell R. Lonser and Daniel K. Resnick. Articles in this issue include: Perioperative Management of Patients with Glioblastoma, Role of Resection in Glioblastoma Management, Advancing Imaging to Enhance Surgery, Intraoperative Imaging for High-Grade Glioma Surgery, Use of Intraoperative Fluorophores, Extent of Resection of Glioblastoma, Functional Mapping for Glioma Surgery: Preoperative Mapping Tools, Functional Mapping for Glioma Surgery: Intraoperative Mapping Tools, Surgical Adjuncts for Glioblastoma, Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors, Stereotactic Laser Ablation of Glioblastoma, Radiosurgery for Glioblastoma, Challenges Associated with Reoperation in Patients with Glioma, and Surgery for Glioblastoma in Elderly Patients.

Stereo EEG has revolutionized the way invasive EEG explorations are performed, facilitating the assessment of more complex cases with increased precision, a lower surgical risk, and better patient outcomes. A Practical Approach to Stereo EEG is the first dedicated reference on stereoelectroencephalography written for trainees, physicians, and technologists involved in invasive EEG evaluation and monitoring. This go-to resource provides a practical overview of the concepts, methodology, technical requirements, and implantation strategies for common and uncommon surgical epilepsies amenable to stereo EEG. Including over three hundred detailed figures, anatomical drawings, and MRI correlations, this guidebook is an indispensable tool for anyone training, practicing, and teaching in the field.With chapters written by leading experts from around the world, the book is divided into 10 sections covering noninvasive evaluation, technical aspects, electrode planning, practical approach for specific epilepsies, surgical placement in adults and children, interpretation, brain mapping, surgical procedures, and outcomes. Chapters integrate highlighted key concepts with illustrative case examples throughout to enhance clinical applicability. Four detailed case discussions of specific epilepsy syndromes covered in the book are also available online to demonstrate the process of patient evaluation, surgical planning, and decision-making in a multidisciplinary patient management conference. A Practical Approach to Stereo EEG is the essential comprehensive clinical handbook for practitioners at any level of training or experience involved in invasive EEG evaluations or working at surgical epilepsy centers. Key Features: Covers all practical aspects of stereo EEG, including the methodology, technical requirements, and strategies to successfully perform and interpret invasive monitoring Highly illustrated cases are interwoven within chapters to heighten clinical use World-class contributors with global expertise provide hands-on experience in successful use of stereo EEG in complex situations Additional online chapter-based narrated cases discuss specific epilepsy syndromes Purchase includes access to ebook available on most devices and computers

An authoritative and comprehensive review of the most important clinical issues facing critically ill neurologic and neurosurgical patients. The authors provide pertinent basic, clinical, diagnostic, and management guidelines for all the conditions commonly encountered in the neurocritical care unit, including the management of autonomic disorders that require critical care, postoperative management, and endovascular treatment. The authors also discuss the latest developments in the monitoring of different body systems, emphasizing the management of cardiorespiratory complications and other medical conditions that may threaten the patient's life. Also detailed are the concepts of intracranial physiology and current neuromonitoring techniques, subjects whose understanding is basic to effective management of critically ill neurologic patients. Numerous tables, figures, diagrams, and radiographs simplify and explicate both the diagnostic and therapeutic processes.

This text provides a comprehensive and contemporary overview of surgical approaches to lesions of the posterior fossa. It will serve as a resource for neurosurgeons and otologists who treat patients with tumors and vascular diseases of the posterior fossa. It provides a concise review of surgical strategies that address the most important pathologies affecting the posterior fossa. It is richly illustrated with photographs and illustrations of the surgical strategies covered. All chapters are written by experts with world-wide recognition for their contributions in their respective subspecialty. Skull Base Surgery of the Posterior Fossa will be of great utility to Neurosurgeons, Otolaryngologists, and Radiation Therapists with an interest in diseases that affect the posterior fossa, as well as Senior Residents in Neurosurgery and Otolaryngology, and Fellows of Skull Base Surgery and Otology.

The Fruits of Reinvention Surgery related to the human head, its compartment and contents has been reinvented over the past 40 years. A number of instruments, most notably the sophisticated medical imaging device and the operating microscope, have principally fueled this evolution. Along the way, endoscopy and sophisticated navigation capabilities have added to the realization of a unique comprehension of normal and abnormal microanatomy permitting corridors and manipu- tions that allow novel strategies for surgery in these highly vital functional areas. Cappabianca, Califano and Iaconetta have created a detailed and fully modern review of methods and strategies related to complex surgery and therapies associated with this robust reinvention. Technical innovations abound! Distinguished practitioners of these unique developments in the history of surgical - terprise present these amazing technical exercises. The catalog of these approaches, inst- mentation, techniques, strategies and manipulations is inspiring and stands as a testimony to the remarkable progress that we have witnessed in recent decades. The presentation in truly "modern" and represents in many aspects pinnacles of operative achievement. We must ask ourselves, what will be next? Los Angeles, November 2009 Michael L.J. Apuzzo, M.D., Ph.D (hon) Preface We belong to a lucky and happy generation, living during a period of many dramatic, if not revolutionary, technical and technological innovations, such as the digital era, which have changed and improved our routine surgical practice, together with the quality and quantity of life of our patients.

The new edition of this indispensable reference features the clinical experience of seasoned experts coupled with fresh perspectives from five new authors, providing you with well-rounded, up-to-date coverage on treating all aspects of nerve injuries. Abundant case studies, descriptive examples of major peripheral nerve injuries and other lesions, and outcome analyses help you implement the most appropriate treatment plan for each individual patient. Plus, the all new full-color design throughout offers exceptional visual guidance on surgical techniques. Proved approaches to the surgical treatment of major peripheral nerve injuries, entrapments, and tumors of both the upper and lower extremities make it easy to understand and perform every procedure. In-depth outcome analyses-based on case studies-and discussions on how the available outcome data affect management help you determine the best treatment protocols. New chapters on Iatrogenic Nerve Injuries and Anesthetic and Positional Palsies keep you current. Expanded coverage on suprascapular nerve injury and entrapment, as well as many other essential updates put the latest knowledge at your disposal. Five new authors, well-trained in the field, offer you fresh perspectives. Step-by-step surgical techniques now in full color illuminate every detail.

The first work of its kind devoted to the pelvis and lower limb, Surgical Anatomy of the Sacral Plexus and Its Branches clearly explains and illustrates this important subset of peripheral nervous system anatomy. Ideal for physicians and residents from a wide range of medical and surgical disciplines, this unique title details new methods of imaging the sacral plexus, as well as its pathology and appropriate surgical approaches. Demonstrates the surgical anatomy of each branch of the sacral plexus using fresh cadaveric dissections. Color-codes nerves to differentiate them from other tissues and dissects them in a layer-by-layer manner. Complies the knowledge and expertise of renowned clinical anatomists and researchers Dr. R. Shane Tubbs and Dr. Joe Iwanaga in this key area of surgical anatomy

Unique in the field, Intrinsic and Skull Base Tumors presents commonly encountered skull base and intrinsic neoplasm cases with side-by-side, case-by-case comparisons that clearly show how various experts would handle the same case. This inaugural volume in the Neurosurgery: Case Comparison Series offers multiple opinions from international experts in neurosurgery who provide various approaches and management styles for the same case. This format allows for quick and helpful comparisons of different ways to approach a lesion, advantages and disadvantages of each approach, and what each expert is looking for in how they would manage a particular case. Offers 3 to 4 expert opinions on each case in a templated format designed to help you quickly make side-by-side comparisons-an ideal learning tool for both trainees and practicing neurosurgeons for board review and case preparation. Helps you easily grasp different approaches to brain tumor management with different expert approaches to the same case and summaries from the editors on the advantages and disadvantages to each approach. Features a wide variety of management decisions, from preoperative studies to surgical approach, surgical adjuncts, and postoperative care, from experts in the field who specialize in different aspects of neurosurgery. Covers low and high grade gliomas, metastatic brain cancers, meningiomas, sellar and parasellar lesions, skull base lesions, and other brain lesions such as colloid cyst, cavernoma, hemangioblastoma, brain abscess, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This volume offers a comprehensive discussion of the stereotactic frames, frameless systems, and radiosurgical procedures utilized in the treatment and control of movement and neurological disorders, Parkinson's disease, chronic pain, spasticity, tumours, epilepsy, and arteriovenous malformations.

With an ever-expanding array of biomaterials and implant devices appearing in the field, Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering helps surgeons assess and utilize the latest technologies to improve the reconstruction of the spine and enhance the reconstitution of diseased spinal segments. With illustrative descriptions of specific clinical scenarios, this guide helps surgeons select the best devices and materials for reconstructive procedures and considers issues in biocompatibility, biostability, and structure-function relationships for enhanced patient outcomes and mobility. With more than 350 figures and photographs, this book: Details current strategies in minimally invasive spine surgery as currently applied to the lumbar spine Covers the myriad of patient factors, orthobiologic grafting alternatives, and technique-driven mechanical options encountered in spinal care and reconstruction Identifies new surgical techniques for spinal fusion, vertebral compression fractures, and arthroplasty Discusses the basic mechanisms and clinical application of currently available operative treatments Supplies the most up-to-date information on the evaluation, diagnosis, and operative treatment of spinal pain, deformity, and disease

Developed over the past 25 years, Cortical Brain Stimulation has emerged as a brand new, cutting-edge option for the treatment of intractable neurological and psychiatric disorders. Devoid of the mortality and disabling morbidity that may accompany deep brain stimulation, stimulating the cortex with a minimally invasive surgical approach had initially proved its worth for the treatment of Central and other Neuropathic Pain Syndromes and later for Parkinson Disease, Dystonia, Stroke and Coma rehabilitation, Epilepsy, Depression and Tinnitus. Written by many of the pioneers in the field, this authoritative treatise is a comprehensive presentation - from surgical details, to clinical results and mechanisms of action. It also provides the busy clinician with comparisons with non-invasive cortical stimulation techniques, such as TMS and tDCS. No other book deals with this form of brain stimulation. The clinician will harness the power of this formidable new therapeutic option, which is being further refined with the advent of closed-loop stimulation. Dr Canavero deciphered the genesis of the central pain syndromes, introduced extradural cortical stimulation for Parkinson Disease and the vegetative state and co-introduced extradural cortical stimulation for stroke rehabilitation. He made worldwide news in 2008 for partially restoring consciousness in two vegetative patients, in 2013 for proposing the HEAVEN/GEMINI protocol for human head transplantation and in 2014 for pushing brain stimulation in the setting of criminal psychopathy. His books include: Central Pain Syndrome, Cambridge Univ. Press, 2011 (2nd ed.), Textbook of therapeutic cortical stimulation, Nova Sci, 2009 and two books in Italian on human sexual behavior.

The inaugural publication of the 7.0 Tesla MRI Brain Atlas: In Vivo Atlas with Cryomacrotome Correlation in 2010 provided readers with a spectacular source of ultra-high resolution images revealing a wealth of details of the brainstem and midbrain structures. This second edition contributes additional knowledge gained as a result of technologic advances and recent research. To facilitate identification and comparison of brain structures and anatomy, a detailed coordination matrix is featured in each image. Updated axial, sagittal, and coronal images are also included. This state-of-the-art and user-friendly reference will provide researchers and clinicians with important new perspectives.

Spinal osteotomy techniques have been dramatically applied as a standard method for severe and rigid spinal deformity. Although clinical results indicate that patients who undergo osteotomy procedures typically experience well deformity correction and ameliorate the clinical appearance, aggressive peri-operative risks and follow-up complications are not rare. More meticulous and standard indication selection, osteotomy plan design and complication prevention strategy and outcome evaluation are critically needed for surgeon majored in spine deformity. The book Spinal Osteotomy is divided into sections that focus on principles of spinal osteotomy, technical and case illustration and outcomes and complications as well as computer navigation and other latest techniques. Each section is heavily illustrated and clearly written for ease of understanding. Orthopedic surgeons, neurosurgeon residents and fellows who want to focus on spinal deformity correction will find this instructive and invaluable.

This issue of Neurosurgery Clinics, edited by Alejandro A. Rabinstein, will focus on Neurocritical Care. Topics will include Anoxic-Ischemic Brain Injury, Practical Approach to Posttraumatic Intracranial Hypertension According to Pathophysiologic Reasoning, Management of Traumatic Brain Injury: An Update, Cortical Spreading Depression and Ischemia in Neurocritical Patients, Targeted Temperature Management in Brain-Injured Patients, Herpes Virus Encephalitis in Adults: Current Knowledge and Old Myths, Primary Acute Neuromuscular Respiratory Failure, Intensive Care Unit-Acquired Weakness, Recent Advances in the Acute Management of Intracerebral Hemorrhage, New Developments in Refractory Status Epilepticus, Acute Cardiac Complications in Critical Brain Disease, Nosocomial Infections in the Neurointensive Care Unit, Neurologic Complications of Solid Organ Transplantation, and Shared Decision Making in Neurocritical Care.

The clinical management of patients with acute brain and spinal cord injury has evolved significantly with the advent of new diagnostic and therapeutic modalities. Acute Brain and Spinal Cord Injury presents the latest medical science and highlights controversies in the clinical management of patients with acute brain and spinal cord injuries. Divided into five sections-traumatic brain injury, ischemic stroke, intracerebral and subarachnoid hemorrhage, and spinal cord injury-this text: Delineates diagnostic and monitoring tools, pharmacotherapies, and interventional and surgical treatments Examines and explores recently published laboratory trials and research Incorporates over 50 diagrams and figures for concise communication of scientific information This stand-alone reference is a powerful tool in helping today's neurologists and neurosurgeons keep abreast of current advancements in brain and spinal cord injury.