This issue of Otolaryngologic Clinics, guest edited by Drs. Abtin Tabaee and Edward D. McCoul, is devoted to Refractory Chronic Rhinosinusitis. Articles in this issue include: Classification of Chronic Rhinosinusitis: Working Towards Personalized Diagnosis; Bacterial Pathogens and the Microbiome; Biofilm and Osteitis; Refractory Chronic Sinusitis with Polyposis; Aspirin-Exacerbated Respiratory Disease; Systemic and Odontogenic Etiologies in Chronic Rhinosinusitis; Genetic and Immune Dysregulation in Chronic Rhinosinusitis; Office Procedures in Refractory Chronic Rhinosinusitis; Topical Therapies and Stents; Revision Functional Endoscopic Sinus Surgery; Extended Endoscopic and Open Sinus Surgery for Refractory Chronic Rhinosinusitis; and An Algorithm for Comprehensive Evaluation and Management of Refractory Chronic Rhinosinusitis.

Bleeding is a major factor that hinders visualization in head and neck surgery and is a risk factor for intraoperative complications and perioperative morbidity. Endoscopic approaches also pose significant technical challenges to managing expected intraoperative bleeding and vascular injury. The approach for this publication in Otolaryngologic Clinics is to provide clinically relevant information in a problem-based manner that encompasses assessment to identify patients with a high risk for vascular complications, pre-operative, intra-operative and post-operative strategies to manage expected bleeding and major vessel injury during endoscopic sinus and skull base surgery for inflammatory and neoplastic diseases. Clinically relevant anatomy, physiology, pharmacology, and surgical and interventional radiology techniques to manage bleeding are outlined and an algorithm for management of major vessel injury such as internal carotid artery injury is presented. Because skull base surgery is generally undertaken as a team approach, this information is relevant to the subspecialized ENT surgeon from rhinology or head and neck specializations, to neurosurgeons, to interventional radiologists, and to neurophysiologists who monitors intraoperative cerebral and cranial nerve activity for these operations. Carl Snyderman leads this issue with Harshita Pant and has composed topics and assembled an expert group of practitioners to provide information. The reader will find this a novel, focused, and indispensable resource on all issues of hemostatis in head and neck surgery.

Experts from childrens' hospitals across the United States discuss diagnosis, treatment, and pathophysiology of head and neck masses in children. Topics include: Branchial cleft cysts; Thyroglossal duct cyst and ectopic thyroid; Vascular malformations; Thyroid nodule and malignancy in children; Lymphoma in pediatrics; Malignancies in the pediatric head and neck - rhabdomyosarcoma and neuroblastoma; Skull base and more including intranasal masses; Tumors of the maxsilla and mandible; Teratoma and dermoid cysts; Inflammatory adenopathy; Disorders and tumors of the salivary glands; Intraoral and lingual lesions; and the Exit procedure. Beyond relevance to Otolaryngologists, this issue of Otolaryngologic Clinics is appropriate for cancer specialists, pediatricians, family practitioners, general surgeons, and pediatric nurse practitioners. Residents training in those fields, as well as Neurosurgery and Ophthalmology, will find this practical.

This book contains 400 EMI MCQ questions, which collectively reflect the breadth of important topics in Otorhinolaryngology, Head and Neck Surgery. The EMIs are presented in four a bite sizea chapters (100 EMIs/chapter). Each chapter is followed by answers with succinct explanations to consolidate knowledge and understanding. Questions are deliberately arranged randomly in each chapter to reflect real life situations. The level of diffi culty of the questions varies, making this book suitable for all ENT surgeons, especially those preparing for professional examinations such as DOHNS (UK), Arab Board, European Board, MRCS (ENT) and FRCS ORL-HNS (UK). This book represents the most up-to-date and comprehensive assessment of post graduate ENT knowledge, with emphasis on the a wheata rather than the a chaff a . It will appeal to those who want to quickly evaluate and update their knowledge, in the shortest possible time. Seven other ENT Tzar books are also available for ENT career development from medical student level to Consultant (www.enttzar.co.uk, www.ricardopersaud.com)

Ear, Nose and Throat for Medical Students: A Case Based Approach is a novel guide aimed at improving your knowledge of common otolaryngology disorders as well as your clinical and diagnostic skills. The content provides a valuable aide for medical students preparing for written finals and OSCE based examinations. The book will also be of interest to GPs wishing to revise their ENT knowledge, and junior doctors starting their first ENT job. The book is helpfully divided into succinct sections, each addressing common pathology pertaining to the ear, nose, throat, head, neck and also paediatric otolaryngology. This book thereby covers a large range of topics you may encounter in exams and clinical practice, and does so in a concise, attractive and accessible manner. Numerous fictional cases have been designed specifically to guide you through the clinical reasoning process from start to finish. Also included is a range of questions to supplement and expand your knowledge of important diseases or presentations. Each case begins with a 'Focusing question' - often regarding diagnosis or aetiology. This is followed by a series of 'Management' questions to test your clinical reasoning, history taking and examination skills. The questions also provide an opportunity to acknowledge the use and importance of investigations and devising treatment plans. Finally, a challenging 'Additional questions' section has been added on to several cases to complete the learning by asking potential viva questions regarding relevant basic science and pathophysiology. The simple-to-read layout and abundance of clinical pictures ensures easy recall of information during outpatient practice and examinations.

Ear, Nose and Throat surgery is a specialty that is often inadequately covered in Medical Schools worldwide and very few junior doctors encounter it during foundation training or internship. As a result, there is always a sense of anxiety and a feeling of entering the unknown when junior doctors, such as core surgical trainees, GP trainees, Foundation and Emergency doctors see patients with ENT conditions requiring urgent care. Currently, there is no concise guide book to address this fundamental issue without subjecting the reader to hours and hours of trawling through lengthy didactic text. With this in mind, and utilising the principles of Pointillism, the authors have put together an excellent succinct guide. The book is divided into five chapters, each consisting of urgent care conditions pertaining to (1) Ear, (2) Nose and Bronchus, (3) Throat and Oesophagus, (4) Neck and Head or (5) Complications of Treatment. All the essential information is clearly provided in 5 logical management steps: history, examination investigation(s), treatment and follow-up. Additional relevant points, tables and figures are provided to further enhance your understanding and retention of the subject matter. Like the previous two books from ENT TZAR team, this guide is lavishly illustrated with clinical photographs to optimise learning and confidence to deal with the challenges of managing urgent care conditions in Otolaryngology.

In this issue of Otolaryngologic Clinics, guest editors Drs. Romaine F. Johnson and Elton M. Lambert bring their considerable expertise to the topic of Pediatric Otolaryngology. Top experts in the field cover key topics such as single-sided deafness, eustachian tube dysfunction, drug-induced sleep endoscopy; drooling and aspiration; pediatric tracheostomy teams; 3-D printing in otolaryngology; and more. Contains 15 relevant, practice-oriented topics including enhanced recovery after surgery; aerodigestive approaches to chronic cough; slide tracheoplasty: tracheal rings and beyond; COVID-19 and pediatric otolaryngology; and more. Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Drs. Michael D. Seidman and Marilene B. Wang bring their considerable expertise to the topic of Complementary and Integrative Medicine and Nutrition in Otolaryngology. Many patients use heath care approaches that are not part of conventional medical care or that may have origins outside of usual Western practice, while also using conventional health care. In this issue, top experts summarize the current knowledge of complementary and integrative medicine and nutrition as they relate to the care of patients in otolaryngology practices, providing a comprehensive resource that physicians and allied health providers can rely on for accurate patient counseling. Contains 19 practice-oriented topics including diet and health; why otolaryngologists should be interested in psychedelic medicine; probiotics for otolaryngology disorders; sinus issues and natural alternatives; CIM and prevention of hearing loss; CIM and the voice; natural alternatives and the common cold/flu; otitis media; and more. Provides in-depth clinical reviews on complementary and integrative medicine and nutrition in otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Drs. Regina Rodman and C. Michael Haben bring their considerable expertise to the topic of Gender Affirmation Surgery in Otolaryngology. Top experts in the field cover key topics such as masculinization laryngoplasty; facial analysis, browlift and brow position; genioplasty for chin reduction; Adam's apple reduction; cheek augmentation; voice tuning refinements with laser; and more. Contains 17 relevant, practice-oriented topics including approach to the transgender patient; impact and expectations of hormone replacement therapy or orchiectomy on the timing of, or necessity for, gender affirmation voice surgery; the role of voice as a source of dysphoria and gender identity; feminization laryngoplasty; voice and speech training for the transgender patient: what the otolaryngologist should know; and more. Provides in-depth clinical reviews on gender affirmation surgery in otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This is an autobiography of Ellis Douek, one of the pioneers of hearing implants, whose name lives on through the middle ear device Douek-MED (TM). Shedding light on the life of a surgeon from the early days of the UK National Health Service, it not only covers the highlights of Douek's medical career but also contains sensational, no-holds-barred tales of his interactions from ordinary patients to well-known singers, kings, emperors and dictators. We read about a social dinner-turned-mass consultation session for the entire Cabinet; using an innovative hearing test to expose a financial scam; a wife who dumped her loyal husband after being cured; a curious encounter with Michael Jackson; and not getting paid by Gaddafi's staff, causing an epic coup by the Libyan dictator on his own embassy. It is at once unflinching and compassionate, offering a searingly honest firsthand account of his trailblazing journey to leave a mark in history.Blending pioneering research and a unique episodic storytelling approach, To Hear Again, To Sing Again is a profound reflection on the relationship between doctor and patient, and one man's quest to make a difference in the world.

In this issue of Otolaryngologic Clinics, guest editors Drs. Joni K. Doherty and Michael Setzen bring their considerable expertise to the topic of Comprehensive Management of Headache for the Otolaryngologist. As many types of headache tend to masquerade as sinus headache, an understanding of the peripheral mechanisms of specific headache types is essential for otolaryngologists to effectively diagnose and treat patients, according to a study published in the American Journal of Otolaryngology. In this issue, top experts in the field address key issues such as novel devices for sinus headache, headache diagnosis in children and adolescents, headache and pregnancy, side-locked and nummular headaches, and much more. Contains 14 relevant, practice-oriented topics including the role of the otolaryngologist in the evaluation and management of headache; "Sinus headache:" rhinogenic headache, nonrhinogenic headache, or migraine; idiopathic intracranial hypertension; neuralgia and atypical facial, ear, and head pain; and more. Provides in-depth clinical reviews on comprehensive management of headache, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This 25th volume of the Evidence-based Clinical Chinese Medicine series provides a multi-faceted 'whole evidence' analysis of the management of rhinosinusitis (sinusitis) using integrative Chinese medicine.Beginning with an overview of how rhinosinusitis is conceptualised and managed in conventional medicine (Chapter 1), the authors summarise the management of rhinosinusitis in contemporary Chinese medicine (Chapter 2) based on clinical guidelines and contemporary books. The third chapter provides detailed analyses of how rhinosinusitis was treated with herbal medicine and acupuncture in past eras based on the classical Chinese literature.The subsequent chapters comprehensively review the current state of the clinical evidence for the integrative application of Chinese herbal medicines (Chapter 5), acupuncture therapies (Chapter 7), other Chinese medicine therapies (Chapter 8) and combination Chinese medicine therapies (Chapter 9), as well as analyse and evaluate the results of these studies from an evidence-based medicine perspective. In Chapter 6, the authors review and summarise experimental evidence for the bioactivity of commonly used Chinese herbs and their constituent compounds. The outcomes of these analyses are summarised and discussed in Chapter 10. Implications for clinical practice and future research are identified.This book provides valuable information for clinicians and students in integrative medicine and Chinese medicine regarding contemporary practice and the current evidence base for Chinese medicine therapies for managing rhinosinusitis, in order to assist clinicians in making evidence-based decisions in patient care. It also provides researchers with a comprehensive survey of the state of the field that can inform future directions for clinical and experimental studies.

In this issue of Otolaryngologic Clinics, Guest Editors Nancy M. Young and Anne Marie Tharpe bring their considerable expertise to the topic of Childhood Hearing Loss. Top experts in the field cover key topics such as Auditory Neuropathy Spectrum Disorder, Cochlear Implantation for Unilateral Hearing Loss, Guidelines and Consensus Statements, and more. Provides in-depth, clinical reviews on Childhood Hearing Loss, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including Mechanisms of Ototoxicity & Otoprotection; Early identification and Management of Congenital CMV; Genetics of Childhood Hearing Loss; The Impact and evaluation of Fatigue and Listening Effort on Children with Hearing Loss; and more.

Offering a practical, clinically focused approach to the use of the three-dimensional exoscope in the field of otolaryngology-head and neck surgery, Exoscope Assisted Surgery in Otorhinolaryngology is an up-to-date, expert guide to the optimal use of this new technology. Written by surgeons with extensive experience in this fast-changing area, this title is an excellent resource for otolaryngologists and oral and maxillofacial surgeons who need a better understanding of the advantages of exoscope technology and its use in various surgical procedures. Synthesizes current evidence-based literature and personal experience regarding the use of exoscopes in otolaryngology-head and neck surgery. Offers a practical approach focused on clinical decision making. Explains exoscopic technology and offers helpful comparisons between the exoscope and microscope in various surgeries. Covers microlaryngeal surgery, laser-assisted endoscopic laryngeal surgery, ear surgery, lateral skull base surgery, exoscope assisted dacryocystorhinostomy, free flap harvesting, and much more. Consolidates today's available information on this timely topic into a single, convenient resource.

This issue of Otolaryngologic Clinics, guest edited by Drs. Sarah K. Wise, Ashkan Monfared, and Nicole C. Schmitt is devoted to Biologics in Otolaryngology. This issue is one of six selected each year by our series consulting editor, Dr. Sujana S. Chandrasekhar. Articles in this issue include: Biologics in otolaryngology overview, Current evidence for biologic therapy in chronic rhinosinusitis with nasal polyposis, Choosing the right patient for biologic therapy in CRSwNP, Knowledge gaps and research needs for biologic therapy in rhinology practice, Mechanisms and practical use of biologic therapies for allergy and asthma indications, Immunotherapeutic strategies in head and neck cancer, Cetuximab in head and neck cancer, Anti-PD-1 immune checkpoint blockade for head and neck cancer, Advances in adoptive cell therapy for head and neck cancer, Biologics for the treatment of recurrent respiratory papillomatosis, Past and future biologics for otologic disorders, Biological treatments for Neurofibromatosis Type II and other skullbase disorders, and Biologics in treatment of autoimmune ear disorders.