Many books from symposia describe the current status in well established fields of research, where much is known and where the loose ends are only details in the picture. The topic dealt with here does not fall into this pattern. The study of time as a parameter in its own right is difficult, and the loose ends tend to do minate the present picture. Although the book does provide the reader with an overview of the field, its main value is probably to act as a source of "food for thought" for those interested in the function of sense organs and nervous systems as substrates for behaviour. The Introduction is intended to provide the readers of the book with a short guide to the topiCS discussed in the different chapters. The rather detailed Index may help those looking for information on specific topiCS. The Index also explains most of the abbreviations used in the book. The basic idea of the Danavox symposia is to invite a small group of experts to discuss a rather narrow theme in sound communication. The small number of active par tiCipants has the advantage of encouraging intense dis cussions and of avoiding overloading the program. On the other hand, selecting the partiCipants is difficult."

Our common interest in surgery of the vertebral artery was born in 1976, when as residents in the same hospital, we attended an attempt by two senior surgeons to treat an aneurysm of the vertebral artery at the C 3 level. Long discussions had preceded this unsuccessful trial, to decide if surgery was indicated and to choose the surgical route. Finally a direct lateral approach was performed, but access was difficult and correct treatment was impossible, resulting in only partial reduction of the aneurysmal pouch. Following this experience, we decided to seek a regular and well defined approach for exposition of the vertebral artery. Review of the literature indicated some surgical attempts, but the descriptions did not give the impression of safety and reproducibility. No landmark on the described surgical route appeared sufficiently reliable. Henry's anatomical work (1917) gave the only accurate description on vertebral artery anatomy, and it became the basis for our work. When the same patient was referred again one year later, after a new stroke in the vertebro-basilar system, we had behind us repetitive experience on cadavers of an original approach to the distal vertebral artery.

Dear colleagues, Promotion of the development of ENT is one of the most important tasks of IFOS (International Federation of Otorhinolaryngology). Apart from organizing the World Congresses it supports different international and regional meetings, organizes symposiums on well determined subjects, etc. Since the last World Congress in 1981, in addition to the Danube Symposium in 1982 and the Congress of ENT Societies in Asia Oceania in 1983, an international symposium was organized in Antwerp by the Belgian ENT Society on evaluation problems of middle ear surgery. This is a very controversial question on which there is no concensus. During a four-day meeting many anatomical and pathological aspects, operative methods, possibilities of the evaluation of the results with computers, were widely discussed. You will find all the lectures presented in this book. I am convinced that these papers will prove to be a good basis for further discussion and hope that finally we shall achieve an international agreement on the evaluation of our results in middle ear surgery. My thanks go to Professor Marquet for organizing the meeting and for publishing the papers. Professor Dr. L. Surjan President of IFOS 10 WELCOME Dear colleagues and especially dear Professor Marquet, In my function as pro-rector of the University of Antwerp I am very proud of welcoming you to the opening of the International Conference on "The Postoperative Evaluation in Middle Ear Surgery." It gives me the opportunity to stress the importance of this congress and to honour Prof. Marquet."

Several years ago Coleman (1981) reported that in 1979 one of the many in ternational cosmetics companies had an annual sales figure of $2. 38 billion, nearly 1. 25 million sales representatives, and over 700 products, the majority of these being for the face. Cash and Cash (1982) noted that in 1979 U. S. consumers spent over $4 million on cosmetic products. They stated that, "Although this practice would seem to be a fascinating aspect of human be havior on the basis of its generality and resilience, social-behavioral scientists have largely ignored the phenomenon so plainly (or pleasingly) in front of their eyes. " Why should people be so concerned with their facial appearance? Many psychologists have argued (e. g., Kleck & Rubenstein, 1975) not only that facial information is usually the first that is available to the perceiver, but also that it is continuously available during social interaction. Maruyama and Miller (1981) stated that "appearance is often the first dimension upon which a stranger can be evaluated. Since people tend to see others as integrated and consistent units, rather than as collections of situation-specific behaviors, a potent and immediately evident basis for an evaluation, such as physical appearance, should intrude into and affect any overall and subsequent evalua tion."

In planning The Handbook volumes on Audition, we, the editors, made the decision that there should be many authors, each writing about the work in the field that he knew best through his own research, rather than a few authors who would review areas of research with which they lacked first hand familiarity. For the purposes of the chapters on Audition, sensory physiology has been defined very broadly to include studies from the many disciplines that contribute to our understanding of the structures concerned with hearing and the processes that take place in these structures in man and in lower animals. A number of chapters on special topics have been included in order to present information that might not be covered by the usual chapters dealing with anatomical, physi ological and behavioral aspects of hearing. We wish to thank all authors of the volumes on Audition for the contributions that they have made. We feel confident that their efforts will also be appreciated by the many scientists and clinicians who will make use of the Handbook for many years to come. WOLF D. KEIDEL WILLIAM D. NEFF Erlangen Bloomington August 1974 Contents Introduction. By G. v. BEKESY t. With 3 Figures. . . . . . . . 1 Chapter 1 Consideration of the Acoustic Stimulus. By R. R. PFEIFFER. With Chapter 2 19 Figures. . . . . . . . . . . . . . . . . . . . . . . . . 9 Comparative Anatomy of the Middle Ear. By O. W. HENSON Jr. With Chapter 3 23 Figures. . . . . . . . . . . . . . . . . . . . . . . 39 . . . . ."

This book has been assembled from the radiographic and photo graphic records of patients presenting to craniofacial units on four continents over 7 years. It is our purpose to illustrate a wide range of craniofacial deformities with the technique of three-dimensional com puted tomography. Many topics are briefly addressed with descriptive text intended to amplify the accompanying images but not to exclude the need for more comprehensive references as recommended in the reading list of each chapter. The ability to generate three-dimensional radiographic images rep resents a successful integration of computed tomography with com puter graphics. Although this technique remains an electronic substi tute for the study of dry skull specimens, it offers a permanent pictorial record of anatomical structures with the opportunity for fu ture interactive data manipulation. It is hoped, therefore, that this work will assist others to gain a more complete understanding of disorders of the craniofacial region. We encourage other surgeons and investigators to examine and employ the techniques used to gather these images but also to ensure that standardized scanning regimens are adapted. The importance of data collection within its full anatomical context was borne out with many of our early studies, which were limited owing to computational con straints. Often an image requirement for surgical intervention is much less than an image necessary for strict scientific inquiry."

Endoscopic Techniques in Plastic and Aesthetic Surgery comprehensively addresses both the aesthetic and reconstructive aspects of endoscopic surgery as applied to plastic surgery. The editors, renowned pioneers of these techniques, have assembled a group of distinguished contributors to present, step-by-step, the operative strategies for incorporation of endoscopic procedures to the armamentarium of the practicing plastic surgeon. The procedures are precisely and exquisitely rendered by 721 illustrations, including over 300 full color endoscopic views and operative photographs. This book is the essential, definitive source for mastery of these state-of-the-art techniques.

This book is based largely upon a series of articles which originally appeared in Update. The purpose of the series was to give medical practitioners an insight into dental and oral disease. The diagnosis of oral disease is not a subject which receives particular emphasis in most medical curricula and it is almost com pletely absent from many. Postgraduate courses in this field are not generally available to medical practitioners. The prevention and early detection of dental and oral disease can be a very positive contribution to the health of our patients. The dental profession sees only about half the population on a regular basis, though it has been shown that over 99 per cent of the population will suffer from oral disease at some time. This places the burden of responsibility on the shoulders of the medical practitioner. There are many diseases which originate in and are peculiar to the oral cavity. Many systemic diseases have their early visible manifestations in this area. The early detection and identification of disease and deformity of the oral cavity is an important part of diagnosis in the field of general medicine. The book is designed to present basic knowledge about the diseases found in the mouth, which will aid in their early recognition, prompt referral and treatment."

The need for better implant materials was a stimulus for the increa sing knowledge of Biomaterial Scientists. Different surgical disciplines were very successful in the use of prostheses, especially because they based their surgery on a good cooperation with fundamental scientists. The use of alloplastic implant materials in the reconstruction of the middle ear has not always been successful. We all know the initial suc cess in the sixties and the disappointments after short term follow-up periods. Because of these failures, Otology missed contact with the new developments in Biomaterial Science. However, we must realize that in the reconstruction of a sound conducting system our most successful results are achieved with alloplastic implants. John Shea introduced the use of Teflonprostheses in the restoration of hearing in otosclerosis and ever since this has been the most rewarding reconstructive middle ear opera tion. With the development of the intact canal wall techniques and the use of homologous implant materials the problems of middle ear surgery see med to be solved. However, we now know that closed techniques have dis advantages after longer post-operative periods and the use of homologous implant materials give problems. Collection of these implants is not al ways easy and the preservation is still in discussion. Furthermore, pro blems of resorption, rejection or fixation give uncertain post-operative results. Middle ear prostheses of different new implant materials are promoted by industry and good results are published, but also disappointments after shorter or longer periods."

A brilliant collection of colour pictures, augmented by appropriate discussion, describing both common and unusual afflictions. Sections on clinical manifestations, histologic findings, differential diagnosis, and treatment, complemented by significant references, have been written by selected authorities in the field. Dermatologists, dentists, and even primary care physicians will find this an indispensable volume in their practices.

This volume describes a new direction in technological and biomedical developments for profoundly deaf individuals. The first section covers topics of tissue characteristics, such as responses to electrical stimulation and computer modelling of cochlea currents. Perception of acoustic signals, responses and behavioral pattern as well as psychophysical aspects are treated in the second part. Part III is addressed to perspectives and challenges of encoding schemes. Reports on studies of acoustic and electrical encoding of temporal information, speech features with cochlear implants as well as psychophysical and speech perceptual studies will allow further strategies for cochlea implants.

Here, one of the most respected otoplasty surgeons has written the definitive book on the latest techniques. Jack Davis brings the plastic surgeon and the otolaryngologist up to date with the newest concepts and methods for reconstructive and aesthetic plastic surgery of the ear. The volume contains such hot topics as secondary otoplasty, "eplasty", "sandwich" methods, radical auriculoplasty and stereotaxic surgery, but also covers histogenesis and growth of cartilage, auricular functional properties and embryology of the external ear. With the authors own beautiful drawings and preceded by a foreword by Dr. Blair Rogers, Otoplasty: Aesthetic and Reconstructive Techniques will undoubtedly fill an important niche in the market.

The sellar region and paranasal sinuses constitute the anatomical sections of the skull base in which pathological entities warrant interdisciplinary management. Processes originating in the paranasal sinuses can reach and involve the skull base in and around the sella, sometimes not respecting the natural dural boundary. On the other hand, lesions involving the sellar block, such as pituitary adenomas and meningiomas, can also extend downwards into the paranasal sinuses. The orbit and cavernous sinus may be subject to involvement and infiltration by both paranasal and sellar pathology. The advancement and new achievements of modern diagnostic procedures, such as high-resolution CT, three-dimensional reconstruc tion, MRI, and MRI angiography, as well as the detailed selective angiographic protocols and endovascular techniques, have increased the possibilities for surgical management of this type of pathology with extra- and intracranial involvement. Long-standing and intense inter disciplinary work has led to sophisticated operative approaches which for benign tumors allow total excision with preservation of structures and function, and for some malignant lesions permit an en bloc resec tion via a combined intracranial-extracranial approach. This volume reflects the work and scientific exchange which took place during the IV International Congress of the Skull Base Study Group, held in Hanover. Leading authorities in the basic sciences including anatomy joined with diagnosticians, clinicians, and surgeons from different fields to evaluate the state of the art of this topic in skull base surgery."

For more than three decades the methods for assessing cell pro liferation have been largely the preserve of experimental biologists, and in their hands such techniques have contributed greatly to our understanding of the dynamic organisation of normal and patho logical tissues. In recent years, with the advent of novel method ologies, there has been increased interest among both pathologists and clinicians, particularly oncologists and others interested in neoplasia, in assessing cell proliferation. This interest has been stimulated by the possibility that indices of cell proliferation may have direct clinical relevance, for example in being useful predictors of outcome in patients with certain forms of malignancy. In addi tion, interest in assessing cell proliferation has been fuelled by the tremendous advances in our understanding of the mechanisms of cell proliferation and their deregulation in pathological processes. Consequently, the time is ripe for a monograph critically reviewing the available methods for assessing cell proliferation, their potential and their problems. We have been particularly concerned to present a balanced view of the advantages and disadvantages of different methods currently available for assessing cell proliferation. The assessment of cell proliferation often requires some familiarity with mathematical methods, but in this book we have attempted to keep detailed mathematical analyses to a minimum. We have asked exponents of each of the well-recognised methods to critically review the tech niques and the ways in which they may be applied to clinical mate rial."

Acquired aural cholesteatoma poses a unique procedural dilemma with regard to pathogenetic research and theory building. Because cholesteatoma spontane ously occurs only in the poorly pneumatized human ear, its pathogenesis is specific to humans. Nonetheless, because of the ethical questions surrounding human experimentation, pathogenetic study has almost exclusively involved nonhuman subjects. Indeed, attempts have failed in almost all animal expe riments except with the gerbil, and even here experimental designs have been improbable compared with human cholesteatoma. Cholesteatoma in the gerbil is useful, therefore, only for the study of pathology and not for human pathogenesis. I hold that the pathogenesis of cholesteatoma will be understood by studying the cholesteatomatous ear, that is, the malpneumatized ear of the human. The anatomical difference between the normal and malpneumatized ear is a probable cause of cholesteatoma. This difference may be found clinically in facial nerve decompression and cholesteatoma surgery, as, for example, facial nerve palsy occurs usually in the normal, well-pneumatized ear. Of course, conventional animal experimentation will not confirm this clinical difference since there is no ideal animal model for the poorly pneumatized human ear. Present surgical techniques for cholesteatoma vary greatly according to indi vidual otosurgeon's opinion. The most extreme difference of opinion is focused on whether to remove the external ear canal wall. Normally, the best option would be not to remove the canal wall if cholesteatoma recurrence can be prevented. Simply put, recurrence of cholesteatoma comes about when its cause has not been removed during primary surgery."

Contemporary laryngology had its beginnings near the close of the 19th century and is probably best exemplified in the work of Morel McKenzie and of Czermak. Subsequent to their pioneering efforts, another surge of interest could be said to have centered about the efforts of the Chevalier Jacksons in the 1920's. After those bold steps, and for almost 40 years, research in laryngology and interest in laryngology continued, but at considerably and increasingly less intense levels, certainly so far as the otolaryngologist population was concerned. In the 1940's Julius Lempert sparked a renaissance in otologic research, deVelopment, and surgery, and exciting new frontiers opened in otology. In our own time, otology remains a large basic and fundamental segment of the otolaryngologic purview, but the flood of new discoveries which followed Lempert, like those which had followed the Jacksons in the 1920's in laryngology, appears to have diminished. When the authors of this publication made acquaintance in the late 1960's, there were approximately 10 centers in the United States for laryngologic research which could be truly designated as voice research facilities. The senior author was at that time instrumental in formulating the major criteria for laboratories to be so designated. In the early 1980's interest in laryngology has revived. At a recent meeting it was possible to list over 40 such laboratories which now were known to the authors over a broad geographic sweep, covering the entire United States.

Often being vastly underrated the human sense of smell plays an essential role in our life, e.g. in food acceptance, fragrance appreciation, and as a warning device for spoiled food, toxic gases and the presence of fire. The book provides a multidisciplinary up-to-date review of the structure and function of the sense of smell and of how it is influenced by the environment and diseases. It is divided into the following 5 sections: - Anatomy, Physiology and Chemistry - Measurement of OlfactoryResponses - Development and Senescense - Basic Characteristics of Human Olfaction - Clinical and Health Aspects of Olfaction.

This book contains a series of articles and summaries regarding surgical voice restoration after or during a total laryngectomy. Most readers will recall the pleasure patients feel when they are able to speak again after years of mute existence. A few simple questions are relevant to the articles contained herein. Firstly, how important is a person's voice? Is it for example as important to man as the dances bees use to convey essential information? Even the most superficial consideration must tell us that the function of the human voice is still more important as we already have a detailed body language of our own, e.g., when we feel pain, joy, love, fear, etc. Without doubt, speech is the basis of knowledge and surely it is the capacity to learn which characterizes the human intellect. Secondly, one may ask whether man was always intended to have a voice? A few every-day observations can provide us with an answer. When little children play together, for instance, they all speak at once and seldom listen to what their neighbors are saying. Obviously, this is b cause it is not so important what they are actually saying as that something is being said at all.

The cerebello-pontine angle has always posed a challenge to the neurosurgeon, the otoneurosurgeon, and the neuroradiologist. Angle masses which are very small and difficult to detect frequently produce symptoms, but may remain silent while growing to exceptional size. The neuroradiologist must have firm knowl edge of the clinical manifestations of the diverse angle lesions in order to tailor his studies to the patients' needs. The majority of angle lesions are benign; thus successful surgery has the potential for complete cure. Angle lesions typically arise in conjunction with vital neurovascular structures, and often displace these away from their expected positions. Large lesions may attenuate the vestibulocochlear and facial nerves and thin them over their dome. Since the nerves often remain functional, the surgeon then faces the need to separate the tumor from the contiguous nerve, with preservation of neurological function. Depending on the exact location and extension of the lesion, resection may best be attempted via otologic or neurosurgical approaches. The neuroradiologist must determine - precisely -the presence, site, size, and extension( s) of the lesion and the displacement of vital neurovascular structures as a guide to selecting the line of surgical attack. Since the arteries, veins, and nerves that traverse the angle are fine structures, the neuroradiologist must perform studies of the highest quality to do his job effectively."

The esophagus, ostensibly a simple tubular structure whose functional role often is minimized and even ignored, is, in re- ality, a highly complex viscus. The problems associated with disorders of the esophagus are not only related to the usual en- tities which may be anticipated in any portion of the gastroin- testinal tract, but include in a major fashion the functional mechanisms indigenous to the pharyngoesophageal and eso- phagogastric junctions. A number of disorders, representative of the classical cate- gories of disease, affect the esophagus. These include the various congenital and developmental abnormalities, of which some are complex. Trauma to the esophagus is not un- common, and infective and inflammatory lesions of this struc- ture are encountered relatively frequently. The different types of neoplasms of the esophagus are relatively few in number, but are commonly observed-the most serious, from the point of view of survival, being carcinoma. The collagen disorders, particularly scleroderma and dermatomyositis, affect the eso- phagus all too often. A miscellaneous group includes such en- tities as achalasia and varices, occurring in varying degrees of frequency. Functional abnormalities of the oropharynx, hypo- pharynx and esophagus, particularly relating to swallowing and the frequently encountered instances of spasm of the pharyngoesophageal and the esophagogastric junctions, consti- tute an important and common source of difficulty in the pa- tient population at large. In this regard, anatomic, radiologic, and physiologic studies of these structures have provided through the years vital data which has proved of considerable VII ...

Vestibular physiology has acquired new interest in the past few years. The development of fast aircraft, beginning during the Second World War and continuing through modern supersonic jets and space travel, has increased dramatically the acceleration range to which man is subjected, from prolonged weightlessness to several gs. The labyrinth measures all kinds of acceleration, including gravity. and therefore has taken on particular impor tance in the study of human health in the Space Age. It is understandable. then, that NASA sponsored the Symposium on Vestibular Function and Morphology. a satellite of the Eighth Annual Meeting of the Society of Neuroscience. held October 30-November 1. 1978, at the University of Pittsburgh, which also supported the symposium. The present volume was developed from papers originally presented there. My strategy in editing this book has been to focus upon the vestibular end organ and its direct connections. both peripheral and central, in order to as sure a coherent discussion of the basics of vestibular function, structure, and ultrastructure. Fortunately, it was possible to secure the contributions of a number of outstanding investigators from both the United States and abroad, including functionally oriented morphologists. ultrastructuralists, biophysicists, and vestibular physiologists. The result is a comprehensive discussion of the main mechanisms of the labyrinth: the transduction pro cess at the receptor level, in the semicircular canals, and in the utricular and saccular maculae; the information transfer through neuronal pathways to the nuclei and the cerebellum; and the general organization of the system."

Although pitch has been considered an important area of auditory research since the birth of modern acoustics in the 19th century, some of the most significant developments in our understanding of this phenomenon have occurred comparatively recently. In auditory physiology, researchers are now identifying cells in the brainstem and cortex that may be involved in the derivation of pitch. In auditory psychophysics, dramatic developments over the last few years have changed our understanding of temporal pitch mechanisms, and of the roles of resolved and unresolved harmonics. Computational modeling has provided new insights into the biological algorithms that may underlie pitch perception. Modern brain imaging techniques have suggested possible cortical locations for pitch mechanisms.

This timely volume brings together the more recent findings, while emphasizing their relation to the discoveries of the past. It brings together insights from several different methodological areas: physiology, psychophysics, comparative, imaging, etc., in addressing a single scientific problem. Pitch perception can be regarded as one of the main problems of hearing, and the multidisciplinary approach of the book provides a valuable reference source for graduate students and academics.

Many pathologists have little acquaintance with ear, nose concomitant biopsy have become commonplace in the and throat pathology. Some receive few specimens from management of throat disorders. It is hoped that. by ENT tissues; others are deterred from deeper study of the publication of this Atlas, pathologists receiving only material that emanates from regions the normal anatomy occasional specimens will be guided in their provision of of which is so forbidding in its complexity and holds no a report helpful to the clinician and those who are involved familiarity through autopsy investigation, for, apart from with a larger ENT service may be providec with a guide the larynx, there is usually no compelling indication for to the deeper understanding of the subject. examination of the ear, nose or throat at postmortem. Yet. The modern tendency in publication of ristopatholog equally with biopsy specimens from other parts of the ical microphotographs is to omit any statement of their body, the pathologist's report is consequential for the magnification, since it will usually be clear to the reader efficient handling of ear, nose and throat illnesses and what order of enlargement is involved. I n this Atlas, sometimes even for the patient's survival."

The cochlea does not just pick up sound, it also produces sounds of low intensity called Otoacoustic Emissions (OAEs). Sounds produced by healthy ears - either spontaneously or in response to stimuli - allow researchers and clinicians to study hearing and cochlear function noninvasively in both animals and humans. This book presents the first serious review of the biological basis of these otoacoustic emissions.

Contents: The Neck and Thorax.- The Larynx and the Thyroid Gland.- The Face.- The Oral Cavity and the Oropharynx.- The Nose.- The Paranasal Sinus and the Retromaxillary Space.- The Eye and its Orbital Adnexa.- The Ear.- The Middle and Posterior Cranial Fossae.- The Skull and the Gross Anatomy of the Central Nervous System.- The Topography and Variations of the Extra- and Intracranial Vessels.- The Paraganglia.- References.- Index of Operations and Surgically Important Anatomic Relationships.- Subject Index.