Following reviews on sleep physiology, regulation, pharmacology,
and the neuronal networks regulating sleep and awakening, as well
as a classification of sleep disorders, this book presents a number
of major breakthroughs in the treatment of those disorders. These
include recently approved drugs for treating insomnia, such as
Doxepin; variations on previously approved molecules, e.g. Zolpidem
sublingual preparation; or new chemical entities in advanced stages
of clinical development, e.g. Orexin antagonists. Further topics
discussed include drugs acting on the GABA receptor, such as
Lorediplon and Eszopiclone; the treatment of excessive daytime
drowsiness with cell therapy and drugs such as Modafinil,
Armodafinil and Sodium oxybate; and the use of Tasimelteon in the
treatment of circadian sleep disorders.
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