Aseptic arthritis of the knee joint was induced in 12 healthy
donkeys, weighing 60 to 85kg by intra- articular injection of 0.3ml
of turpentine oil. The animals were randomly divided into 2 groups
A and B of 6 animals each. Group A served as a control whereas in
Group B anti-arthritic drug, diclofenac sodium (Diclocare 5%) was
administered intramuscularly at the dose rate of 2.5mg/kg body
weight daily for 5-6 days starting one day after the induction of
arthritis. In group B, the joint circumference became normal on 6th
day after induction of arthritis while in group A (control), the
joint circumference took 16 to 20 days to become normal. According
to this trial, diclofenac sodium provided an early return to normal
stance and weight bearing in treated group B, taking longer time in
control group A. No significant change in blood Haemoglobin, Total
erythrocyte count, Total leukocyte count, Erythrocyte sedimentation
rate and Packed cell volume was observed in control and treated
animals. It is concluded that diclofenac sodium is an effective
treatment for arthritis in donkeys.
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