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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections (Hardcover, 2012 ed.)
Loot Price: R6,323
Discovery Miles 63 230
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Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections (Hardcover, 2012 ed.)
Series: Advances in Neurobiology, 6
Expected to ship within 10 - 15 working days
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Proline-rich polypeptides - in particular (PRP-1) galarmin and its
structural analogues - are, when isolated from the neurosecretory
granules of neurohypophysis of humans and animals, a new type of
hypothalamic peptides. They work against aerobic, anaerobic,
gram-positive, and gram-negative microorganisms in vivo, and do not
have etiotropic properties. They are unique and capable substitutes
to antibiotics, and, moreover, may be effective against strains,
such as MRSA, that develop resistance to antibiotics. Galarmin, a
component of the brain neuroendocrine system produced by the
neurosecretory cells of hypothalamus, possesses immunomodulative,
neuroprotective, antioxidant, antitumorigenic and hematopoietic
properties. Moreover, galarmin and its structural analogues are
powerful anti-inflammatory compounds. In addition to presenting a
full overview of the neuroimmune system, it emphasizes the
antibacterial, neuroprotective, and neuroregenerative properties of
proline-rich polypeptides. It investigates the mechanism of
galarmin's action during different infectious processes, where it
targets such dangerous pathogens as Bacillus anthracis, Clostridium
perfringens, Mycobacterium tuberculosis, and Methycillin resistant
Staphylococcus aureus. This research is important from both a
theoretical and a clinical point of view, creating new prospects
for the modern pharmaceutical industry and neuroendocrine,
neuroimmunological sciences. Dr. Galoyan is a pioneer of the
specialized field of neuroimmunology. During his 45-year long
career, he has discovered a neuroendocrine immune system of the
brain and identified a new type of brain cytokines: proline-rich
polypeptides. The most important of these, PRP-1 (galarmin) has
been shown to possess antibacterial properties and protect from
certain neurotoxins.
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