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Gene Regulation by Steroid Hormones IV (Paperback, Softcover reprint of the original 1st ed. 1989)
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Gene Regulation by Steroid Hormones IV (Paperback, Softcover reprint of the original 1st ed. 1989)
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The first Meadowbrook Symposium was held in 1978 and during the
intervening ten years our knowledge concerning how steroid hormones
function at the level of gene expression has advanced by leaps and
bounds. In this volume, which sum marizes our fourth meeting, these
advances are very evident. What seemed like science fiction ten
years ago has become commonplace science. Who would have imagined
that we could synthesize a nucleotide sequence that binds a
specific steroid receptor and acts as a controlling element for
gene expression? No one; but as is evident from the results
reported in several chapters, this technique is yielding a wealth
of information. Using these and other techniques it has become
apparent that gene transcription is controlled by interactions
between transacting factors and DNA recognition sequences (response
elements). These transacting factors appear to be members of a
large gene family that includes steroid hormone receptors,
transcription factors, protooncogenes and homeobox proteins. Thus a
great deal has been learned, but as usual, questions remain. Many
of these questions are posed by the findings and observations found
in several chapters in this volume. Non hormone binding forms of
steroid receptors and their relevance to receptor down regulation,
recycling and biological response remain a mystery. The
quantitative relationship between receptor binding and biological
response still presents agonizing problems. These and many other
intriguing questions are discussed in this volume and set the stage
for what should be a most rewarding time in endocrinology. Winter
1989 ARUN K."
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