This first guide devoted to this burgeoning topic, this
authoritative reference presents the current understanding of the
phenomenon of aseptic loosening of total joint replacements from
the molecular and cellular mechanisms of periprosthetic bone loss
to the clinical presentation and management strategies-reviewing
the properties of ceramic, metal, and polymer materials used in the
replacement of joints, as well as current research on bone
remodeling, wear resistance, the long-term care of implants, and
emerging developments in gene therapy and tissue engineering.
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