In Glutamate and Addiction, world-renowned scientific experts
critically review all of the evidence for the role of glutamatergic
systems in opiate, stimulant, and alcohol addiction. Using a
variety of pharmacological, biochemical, genetic, and brain imaging
techniques, these investigators show precisely how glutamate
affects such addictions and how modifying certain elements of the
glutamatergic system appear to alleviate particular components of
addiction. Their survey takes in both clinical approaches using
medications that influence glutamate and cutting-edge preclinical
approaches that manipulate specific subtypes of glutamate receptors
or specific substrates of the "glutamate cascade" to determine
their roles in various addictive states.
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