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Free Radicals in Biology and Medicine (Paperback, 5th Revised edition)
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Free Radicals in Biology and Medicine (Paperback, 5th Revised edition)
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Free Radicals in Biology and Medicine has become a classic text in
the field of free radical and antioxidant research. Now in its
fifth edition, the book has been comprehensively rewritten and
updated whilst maintaining the clarity of its predecessors. Two new
chapters discuss 'in vivo' and 'dietary' antioxidants, the first
emphasising the role of peroxiredoxins and integrated defence
mechanisms which allow useful roles for ROS, and the second
containing new information on the role of fruits, vegetables, and
vitamins in health and disease. This new edition also contains
expanded coverage of the mechanisms of oxidative damage to lipids,
DNA, and proteins (and the repair of such damage), and the roles
played by reactive species in signal transduction, cell survival,
death, human reproduction, defence mechanisms of animals and plants
against pathogens, and other important biological events. The
methodologies available to measure reactive species and oxidative
damage (and their potential pitfalls) have been fully updated, as
have the topics of phagocyte ROS production, NADPH oxidase enzymes,
and toxicology. There is a detailed and critical evaluation of the
role of free radicals and other reactive species in human diseases,
especially cancer, cardiovascular, chronic inflammatory and
neurodegenerative diseases. New aspects of ageing are discussed in
the context of the free radical theory of ageing. This book is
recommended as a comprehensive introduction to the field for
students, educators, clinicians, and researchers. It will also be
an invaluable companion to all those interested in the role of free
radicals in the life and biomedical sciences.
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