The efficacy of many useful drugs can be improved by carrying out
certain pharmaceutical manipulations in delivery route e.g. by
transdermal drug delivery system. However, excellent impervious
nature of stratum corneum restricts both the type and number of
drugs that can be delivered to the systemic circulation by this
route. A popular approach for increasing the percutaneous
permeation of drug is to incorporate penetration enhancers into the
formulations. The use of synthetic chemical enhancers for enhancing
the percutaneous permeation of drugs is decreasing due to their
long term effects and potential systemic toxicity. Hence, the main
objective of this study was to evaluate the influence of triterpene
and steroidal saponins on percutaneous permeation of carvedilol and
to understand the mechanism(s) responsible for this effect.
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