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HLA Class II Antigens - A Comprehensive Review of Structure and Function (Paperback, Softcover reprint of the original 1st ed. 1986)
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HLA Class II Antigens - A Comprehensive Review of Structure and Function (Paperback, Softcover reprint of the original 1st ed. 1986)
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This volume deals with the structure and function of molecules that
have, during the last decade, turned out to have a central role in
immune responses. Trans plantation antigens were discovered and
characterized by Gorer about 50 years ago, and the biological basis
for the unequalled complexity of their variability between
individuals within a species, in spite of extreme conservation
between species, was the subject of intense research and discussion
for many years. During the days of belief in "immune surveillance"
against spontaneously developing tumors, it was suggested that
histoincompatibility between members of one species would prevent
cancer from being a contagious disease and thus a threat to the
species. Immunologists involved in human transplantation had to
learn and care about the complexity, especially after 1967, when it
was found that HLA antigens were the products of the human MHC.
Rejection of HLA-identical sib kidney grafts was so rare, even in
those days, that cases of rejection were described in scientific
papers."
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