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The Cytoskeleton - 45. Colloquium der Gesellschaft fur Biologische Chemie 14.-16. April 1994 in Mosbach/Baden (Paperback, Softcover reprint of the original 1st ed. 1995)
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The Cytoskeleton - 45. Colloquium der Gesellschaft fur Biologische Chemie 14.-16. April 1994 in Mosbach/Baden (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Colloquium der Gesellschaft fur Biologische Chemie in Mosbach Baden, 45
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This volume contains the proceedings of the 45th Mosbach Colloquium
of the German Society for Biological Chemistry (GBCh). The 1994
meeting was the first in this series devoted to the cytoskeleton.
This complex system enables the eukaryotic cell to form discrete
contacts with neighboring cells and the extracellular matrix, to
differentiate, to move, change shape, transport organelles, and
proliferate. These diverse tasks are performed by three distinct
fibrillar networks: microfilaments, microtubules, and intermediate
filaments, which are composed of structural and regulatory
elements. The precise interplay between the components in time and
space determines which of the various functions is performed. The
rapid progress made in this field is best exemplified by the recent
unraveling of the molecular mechanism of intracellular movement.
Here, the modem microscopies of today allow the motility to be
visualized in realtime. Molecular biology has dissected the
functional domains of the motor proteins involved and provided
material required for biochemical studies as well as structure
analysis by X-ray diffraction and NMR. Thus, it is now possible to
integrate cellular behavior and molecular structure in a unifying
picture. Other recent advances in the field point to the role of
cytoskeletol proteins in human diseases, from allergies to skin
blistering, atrophies, and Alzheimers's disease. The book is an
up-to-date account of the field told by an international set of
experts, a broad introduction to newcomers, and a valuable
reference for practitioners. January 1995 Brigitte M.
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