Concepts and Models for Drug Permeability Studies - Cell and Tissue based In Vitro Culture Models (2nd edition)

Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition summarizes the most important developments in in vitro models for predicting the permeability of drugs. The book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition is a critical reference for drug discovery and drug formulation scientists interested on delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use the book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

General

Imprint:	Woodhead Publishing Ltd
Country of origin:	United States
Release date:	February 2024
First published:	2024
Authors:	Bruno Sarmento • Catarina Leite Pereira • José Das Neves
Dimensions:	229 x 152mm (L x W)
Pages:	500
Edition:	2nd edition
ISBN-13:	978-0-443-15510-9
Categories:	Books Promotions
LSN:	0-443-15510-0
Barcode:	9780443155109

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