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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Molecular Design and Bioorganic Catalysis (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R4,350
Discovery Miles 43 500
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Molecular Design and Bioorganic Catalysis (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: NATO Science Series C, 478
Expected to ship within 10 - 15 working days
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One of the most active areas of contemporary organic chemistry
involves the search for new catalysts that borrow concepts,
strategies and even components from enzymes but yet are not found
in nature. Such artificial enzymes not only give enormous insights
into the mechanisms of enzyme catalysis but also offer the
potential for catalyzing a wide range of chemical reactions with no
counterpart in nature. Several approaches have been taken in the
deVelopment of new catalysts, some based on biological methods and
others on synthetic techniques. Site directed mutagenesis has
allowed the direct replacement of amino acids in an enzyme with
resulting changes in stability, selectivity and mechanism. Recent
developments have shown that even non-natural amino acids can be
incorporated into proteins and also that enzymes can function
effectively in organic solvents. A different biological route to
artificial enzymes has exploited the immune system and its ability
to generate millions of antibodies to a given antigen. Novel
antigens have been designed to mimic the transition states of
chemical reactions. Antibodies elicited against these antigens thus
contain an active site that is complementary to transition state
structure and can potentially catalyze target reactions. A broad
range of reactions can now be 6 catalyzed using the method with
rate accelerations reaching 10 compared to the control reactions.
Protein engineering and catalytic antibodies represent complex
solutions to the problem of artificial enzymes. Their complexity is
however their principal limitation.
General
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