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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Mitochondrial Function and Biogenesis (Paperback, Softcover reprint of hardcover 1st ed. 2004)
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Mitochondrial Function and Biogenesis (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Series: Topics in Current Genetics, 8
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Mitochondria are complex organelles, possessing a double-membrane
and even their own genome, the mtDNA. They play a pivotal role in
cellular metabolism, respiration, and production of ATP essential
for the normal function of all human organ systems. It is not
surprising, therefore, that genetic defects of mitochondrial
functions cause a wide spectrum of human diseases. This book
provides the first modern and truly comprehensive coverage of the
biochemistry, genetics, and pathology of mitochondria in different
organisms. It particularly focuses on the recent advances in our
understanding of basic mitochondrial research to the consequences
of dysfunction at the molecular level. The 13 contributions written
by leading researchers in the field include topics such as:
mitochondrial genome evolution and mtDNA stability, mitochondrial
biogenesis and protein quality control, mitochondrial morphology,
assembly and function of the mitochondrial energy generation
apparatus and mitochondrial metabolic pathways. These are
particularly oriented to link in these various mitochondrial
pathways to the clinical consequences of their dysfunctions.
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