Allergy is developing into one of the most prevalent diseases
affecting individuals in the very early days of life. While the
cause of this epidemic is still unclear, it appears that the
westernized life style is playing an important role, which includes
nutrition, possibly air pollution as well as hygienic conditions.
While epidemiologic studies were able to narrow down these factors,
basic research discovered novel mechanisms that control the
organisms tolerance against allergens. Particularly interesting is
the role of microorganisms that colonize or infect a host and
thereby cause damage and immunological activation followed by
sensitization or exacerbation of already existing sensitizations.
However at the same time microbial activation of the immune system
can help to generate a protective immunity that prevents allergen
sensitization. The current book is collecting these evidences and
connects epidemiologic and clinical mechanistic knowledge. Only the
synthesis of this knowledge will help to find solutions to the
ongoing allergy epidemic in terms of public health activities,
prevention and therapy.
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