The present research works carried out with the aim to prepare
suspension dosage form using these microparticles for oral use.
Solid Dosage forms are difficult for Pediatric, Geriatric patient
& Dysphasic patients so for that patients the suspension dosage
form more favorable than other solid dosage form. Albendazole drug
has poor oral bioavailability (>5%) & a delayed release
microspheric suspension of this drug would improve patient
compliance & ease of swallowing. Microencapsulate facilitate
the targeting of drug & mask the metallic taste of drug. The %
yield was higher in the solvent evaporation method, in the spray
drying the % yield was less that was drawback of the spray drying
method. The % entrapment efficiency was good in the both method.
Spray drying method is more reproducible than the solvent
evaporation method. The stability study results show similar values
as at the initial time. So, the formulation was stable and had no
significant change in drug release profile & drug content on
storage for a long time. So the suspension can effectively used for
pediatric and geriatric patients. In vivo study will use for
confirmatory study.
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