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Alzheimer’s Disease Research - What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (1st ed. 2023)
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Alzheimer’s Disease Research - What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (1st ed. 2023)
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This book highlights the key phases and central findings of
Alzheimer’s Disease research since the introduction of the label
‘Alzheimer’s Disease’ in 1910. The author, Christian Behl,
puts dementia research in the context of the respective zeitgeist
and summarizes the paths that have led to the currently available
Alzheimer’s drugs. As the reader is taken through the major
developments in Alzheimer's Disease research, particularly over the
past thirty years, Behl poses critical questions: Why are the exact
causes of Alzheimer's Disease still in the dark, despite all the
immense, worldwide research efforts in academia as well as in the
pharmaceutical industry? Why has the majority of an entire research
field kept focusing on a single hypothesis that establishes the
deposition of the amyloid beta peptide in the brain as the key
trigger of Alzheimer's pathology, even though this concept has
still not been convincingly proven in the clinics? Are there other
hypotheses that might explain the pathogenesis of this complex
brain disease, and if so, why were these perspectives not
adequately followed? In this book, Behl tries to answer these
questions. Starting with the historical background, the author
illustrates the long and arduous research journey, its numerous
setbacks, and the many alternative explanations for the disease,
which have started gaining increasing attention and acceptance in
the Alzheimer’s research community only more recently.Â
With his deep dive into the history and progression of this
research, including the most recent developments, Behl explains why
he believes that it is high time to promote a paradigm shift in
Alzheimer’s Disease research. The book is written for all
researchers in the fields of neurobiology and neurodegeneration, as
well as other biomedical fields, who would like to gain a broad and
beyond the surface insight into (the key developments of) one of
the most promoted research fields of our time. With its extensive
literature references and over 100 illustrations, the book is also
attractive for students and interested lay persons. Elaborating on
all the different aspects and research approaches of this research
field, the author aims to convince the reader that the underlying
causes of Alzheimer’s Disease may be much more complex than
previously thought and that this must be considered for future
research directions. While he hopes that the Alzheimer’s research
community is finally ready to shed its ‘amyloid-straitjacket’
that has hampered progress for too long, he is also convinced that
a much-needed paradigm shift can guide future Alzheimer’s Disease
research and provide a new and broader perspective on this
age-dependent brain disease.
General
Imprint: |
Springer International Publishing AG
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Country of origin: |
Switzerland |
Release date: |
July 2023 |
First published: |
2023 |
Authors: |
Christian Behl
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Dimensions: |
235 x 155mm (L x W) |
Pages: |
652 |
Edition: |
1st ed. 2023 |
ISBN-13: |
978-3-03-131569-5 |
Categories: |
Books
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LSN: |
3-03-131569-3 |
Barcode: |
9783031315695 |
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