This second book of the three-volume collection "Ion Transport in
Tumor Biology" helps readers gain comprehensive knowledge of
the pathophysiology of cancer. The authors highlight that ion
transport proteins, channels and transporters - collectively
referred to as the transportome - are significantly involved in the
development and progression of cancer. Nearly 90% of
malignant tumor diseases originate from epithelial cells, the
function of which, for the most part, is based on the transportome.
This volume focuses on molecular principles by showing
that dysregulated expression and/or function of ion
transporters have been correlated with malignancy in the vast
majority of tumor diseases. Within the story of the various
chapters, the authors line out various malfunctions of the
transportome and where they can be found at different stages of the
metastatic cascade. The authors describe how the interactions
between the tumor cells' transportome and the environment reinforce
mesenchymal behaviour of cancer cells and contribute to their
uncontrolled proliferation, migration, invasion, intra- and
extravasation up to the formation of metastases. As part of
a three-volume collection, this book will fascinate members of the
active research community, as well as clinicians from the cancer
field.
General
| Imprint: |
Springer Nature Switzerland AG
|
| Country of origin: |
Switzerland |
| Series: |
Reviews of Physiology, Biochemistry and Pharmacology, 182 |
| Release date: |
April 2023 |
| First published: |
2022 |
| Editors: |
Christian Stock
• Luis A. Pardo
|
| Dimensions: |
235 x 155mm (L x W) |
| Pages: |
175 |
| Edition: |
1st ed. 2022 |
| ISBN-13: |
978-3-03-099802-8 |
| Categories: |
Books
|
| LSN: |
3-03-099802-9 |
| Barcode: |
9783030998028 |
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