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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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Mixture Toxicity - Linking Approaches from Ecological and Human Toxicology (Hardcover)
Loot Price: R1,238
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Mixture Toxicity - Linking Approaches from Ecological and Human Toxicology (Hardcover)
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In the last decade and a half, great progress has been made in the
development of concepts and models for mixture toxicity, both in
human and environmental toxicology. However, due to their different
protection goals, developments have often progressed in parallel
but with little integration. Arguably the first book to clearly
link ecotoxicology and classic human toxicology, Mixture Toxicity:
Linking Approaches from Ecological and Human Toxicology
incorporates extensive reviews of exposure to toxicants,
toxicokinetics and toxicodynamics, toxicity of mixtures, and risk
assessment. The book examines developments in both fields, compares
and contrasts their current state of the art, and identifies where
one field can learn from the other. Each chapter provides an
essential overview of the state of the art in both human and
ecotoxicological mixture risk assessment, focusing on the work
published in the last fifteen years. The coverage progresses from
exposure to risk assessment, at each step identifying the special
complications typically raised by mixtures. Based on in-depth
discussions among specialists representing different disciplines
and approaches, the chapters each address: Exposure - how to
quantify the amounts of chemicals that may enter the living
organism Kinetics, dynamics, and metabolism - how the chemicals
enter an organism, travel within the organism, how they are
metabolized and reach the target site, and explain development of
toxicity with time Toxicity - what are the chemicals' detrimental
effects on the organism Test design and complex mixture
characterization - how chemicals interact, how to measure effects
of mixtures, and how to identify responsible chemicals Risk
assessment - how to assess for risks in humans and the environment
An unusual combination of different points of view on exposure to
and risk assessment of chemical mixtures, this book summarizes
current knowledge on combined effects of toxicant mixtures,
information that is generally only available in a very fragmented
form as individual journal papers. It identifies possible
crosslinks and includes recommendations for mutual developments
that can improve the state of knowledge on mixture toxicity and
ultimately lead to better and more integrated risk assessment.
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