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Molecular Mechanisms in Visual Transduction, Volume 3 (Hardcover)
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Molecular Mechanisms in Visual Transduction, Volume 3 (Hardcover)
Series: Handbook of Biological Physics
Expected to ship within 12 - 19 working days
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Molecular mechanisms in visual transduction is presently one of the
most intensely studied areas in the field of signal transduction
research in biological cells. Because the sense of vision plays a
primary role in animal biology, and thus has been subject to long
evolutionary development, the molecular and cellular mechanisms
underlying vision have a high degree of sensitivity and
versatility. The aims of visual transduction research are
first
to determine which molecules participate, and then to understand
how they act in concert to produce the exquisite electrical
responses of the photoreceptor cells.
Since the 1940s 1] we have known that rod vision begins with the
capture of a quantum of energy, a photon, by a visual pigment
molecule, rhodopsin. As the function of photon absorption is to
convert the visual pigment molecule into a G-protein activating
state, the structural details of the visual pigments must be
explained from the perspective of their role in activating their
specific G-proteins. Thus, Chapters 1-3 of this Handbook
extensively cover the physico-chemical molecular characteristics of
the vertebrate rhodopsins. Following photoconversion and G-protein
activation, the phototransduction cascade leads to modifications of
the population of closed and open ion channels in the photoreceptor
plasma membrane, and thereby to the electrical response. The nature
of the channels of vertebrate photoreceptors is examined in Chapter
4, and Chapter 5 integrates the present body of knowledge of the
activation steps in the cascade into a quantitative framework. Once
the phototransduction cascade is activated, it must be subsequently
silenced. The various molecular mechanisms participating in
inactivation are
treated in Chapters 1-4 and especially Chapter 5. Molecular biology
is now an indispensable tool in signal transduction studies.
Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual
pigments have been characterized and cloned. The genetics and
evolutionary aspects of this great subfamily of G-protein
activating receptors are intriguing as they present a natural probe
for the intimate relationship between structure and function of the
visual pigments. Understanding the spectral characteristics from
the molecular composition can be expected to
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