For more than 25 years clinicians and scientists have been trying
to improve the treatment of acute hepatic failure. Several devices
were developed and hemodialysis procedures were refined. The
treatment of fulminant hepatic failure and end-stage liver
cirrhosis by liver transplantation became a standard procedure.
However, for the successful management of critical situations
before and after liver surgery, artificial liver support is still
needed.
This book is the proceedings of the Falk Symposium No. 145 on a
~Artificial Liver Supporta (TM), held on 27--28 January 2005 in
Ulm, Germany, and provides an overview of the possibilities and
limitations of the existing procedures and devices available for
artificial liver support.
The results achieved with albumin dialysis (MARS System), the
Prometheus System, and dialysis and hemofiltration or plasma
exchange as well as modular extracorporeal liver support (MELS) and
the Amsterdam bioartificial liver are discussed in detail regarding
their effects in different clinical situations.
In the second half of the book, the remaining problems and
expectations for the future of clinical hepatocyte transplantation
and stem cell therapy are elucidated.
Leading experts in the fields of artificial devices,
bioartificial devices, hepatocyte transplantation and stem cells
present the latest data on these topics. Their experience and their
data are summarized in this volume, thus providing an exceptional
overview of the problems and future perspectives in the field of
artificial liver support.
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