While drug therapies developed in the last 80 years have markedly
improved treatment outcomes and the management of some types of
cancers, the lack of effectiveness and side effects associated with
the most common treatment types remain unacceptable. However,
recent technological advances are leading to improved therapies
based on targeting distinct biological pathways in cancer cells.
Chemistry and Pharmacology of Anticancer Drugs is a comprehensive
survey of all families of anticancer agents and therapeutic
approaches currently in use or in advanced stages of clinical
trials, including biological-based therapies. The book is unique in
providing molecular structures for all anticancer agents,
discussing them in terms of history of development, chemistry,
mechanism of action, structure-function relationships, and
pharmacology. It also provides relevant information on side
effects, dosing, and formulation. The authors, renowned scientists
in cancer research and drug discovery, also provide up-to-date
information on the drug discovery process, including discussions of
new research tools, tumor-targeting strategies, and fundamental
concepts in the relatively new areas of precision medicine and
chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is
an indispensable resource for cancer researchers, medicinal
chemists and other biomedical scientists involved in the
development of new anticancer therapies. Its breadth of coverage,
clear explanations, and illustrations also make it suitable for
undergraduate and postgraduate courses in medicine, pharmacy,
nursing, dentistry, nutrition, the biomedical sciences, and related
disciplines.Key Features: Summarizes the fundamental causes of
cancer, modes of treatment, and strategies for cancer drug
discovery Brings together a broad spectrum of information relating
to the chemistry and pharmacology of all families of anticancer
agents and therapies Includes up-to-date information on
cutting-edge aspects of cancer treatments such as biomarkers,
pharmacogenetics, and pharmacogenomics Features new chapters on the
"Evolution of Anticancer Therapies", "Antibody-Based Therapies",
and "Cancer Chemoprevention"
General
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