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CHAPTER III. DETERMINATION OF THE SEAT OF GERMINATION FROM THE
SYMPTOMS AND SIGNS. That the virus-germ of rabies " resides" in
nervous substance, and especially in the more substantial tracts of
the spinal axis, as the bulb and lumbar-swelling where the
nerve-fibre, as distinguished from the nerve-cell, is the
predominant element, is established beyond question by the
experimental investigation. But this conclusion is not less clearly
arrived at by a study of the symptomatic characteristics of the
malady in any of its modifications and "varieties." When one comes
face to face with the active, actual disease itself, the symptoms
and signs, if they yield little positive information as to the true
nature of the malady, nevertheless afford unmistakeable evidence as
to the specific seat of cultivation of the pathogenic
microorganism. It is true that there are hardly two cases of
canine-rabies or hydrophobia where the active phenomena are exactly
alike. Every case shows its own symptoms and signs, not less than
its own train of lesions. In spite of this fact, the clinical
characteristics or symptomatic indications, such as they are, are
constant enough to be of great value as evidence of the specific
seat of the pathogenic micro-organism. Every symptom or sign, as it
arises, points with an increasingly glowing distinctness to the
.central nervous system as the prime centre of the disturbance.
Obviously enough, from such signs, the entire nervous system is,
from beginning to end of the disease, in a state of more or less
chaotic discord. Intense excitability, if it be a "furious" or
convulsive case, or, if it be a paralytic-rabies, the most extreme
collapse and prostration, excruciating hyper- eesthesia, on the one
hand, and all over the periphery, or the profoundest analgesia a...
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