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siRNA Design - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R4,439
Discovery Miles 44 390
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siRNA Design - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: Methods in Molecular Biology, 942
Expected to ship within 10 - 15 working days
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Total price: R4,449
Discovery Miles: 44 490
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The discovery of RNA interference (RNAi) as a methodology for gene
silencing has revolutionized biological research, providing an
invaluable avenue for therapeutics, and small interfering RNA
(siRNA) is the most common strategy utilized for enacting RNAi.
siRNA Design: Methods and Protocols offers expertly crafted
guidelines and protocols for the selection of siRNA targeting
sequences, for the strategic incorporation of chemical
modifications, and for advantageous structural modifications to the
classic siRNA design. Protocols are provided for using endogenous
cellular machinery to produce siRNA from optimized precursor short
hairpin RNA (shRNA) and artificial microRNA (amiRNA) molecules.
Strategies are also described for specific applications such as
immunostimulatory siRNA that may provide therapeutic benefit
against viral infections in mammals, the simultaneous targeting of
multiple siRNAs, and siRNA-mediated crop virus resistance. The
design of RNAi for gene silencing in embryonic, invertebrate, and
plant systems requires a variety of unique approaches, several of
which are described towards the end of this volume. Written for the
highly successful Methods in Molecular Biology (TM) series, this
work contains the kind of detailed description and implementation
advice that guarantees successful results. Authoritative and easy
to use, siRNA Design: Methods and Protocols will provide
researchers, educators, clinicians, and biotech specialists with a
broad understanding of the issues in RNAi and how they can be
overcome strategically through design.
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