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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Excitation-Contraction Coupling and Cardiac Contractile Force (Hardcover, 2nd ed. 2001)
Loot Price: R5,842
Discovery Miles 58 420
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Excitation-Contraction Coupling and Cardiac Contractile Force (Hardcover, 2nd ed. 2001)
Series: Developments in Cardiovascular Medicine, 237
Expected to ship within 10 - 15 working days
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How is the heartbeat generated? What controls the strength of
contraction of heart muscle? What are the links between cardiac
structure and function? How does our understanding of skeletal and
smooth muscle and non-muscle cells influence our thinking about
force development in the heart? Are there important species
differences in how contraction is regulated in the heart? How do
the new molecular data fit together in understanding the heart
beat? What goes wrong in ischemia, hypertrophy, and heart failure?
This book paints a modern portrait' of how the heart works and in
this picture the author shows a close-up of the structural,
biochemical, and physiological links between excitation and
contraction. The author takes the reader through a series of
important, interrelated topics with great clarity and continuity
and also includes many useful illustrations and tables. The book
starts by considering the cellular structures involved in
excitation-contraction coupling and then described the
characteristics of the myofilaments as the end effector of
excitation-contraction coupling. A general scheme of calcium
regulation is described and the possible sources and sinks of
calcium are discussed in simple, but quantitative terms. The
cardiac action potential and its many underlying currents are
reviewed. Then the characteristics of some key calcium transport
systems (calcium channels, sodium/calcium exchange and SR calcium
uptake and release) are discussed in detail. This is then built
into a more integrated picture of calcium regulation in succeeding
chapters by detailed discussions of excitation-calcium coupling
mechanisms (in skeletal, cardiac, and smooth muscle), the interplay
betweencalcium regulatory processes, and finally mechanisms of
cardiac inotropy, calcium overload, and dysfunction (e.g.,
ischemia, hypertrophy, and heart failure). Excitation-Contraction
Coupling and Cardiac Contractile Force &endash; Second Edition
is an invaluable source of information for anyone who is interested
in how the heart beat is controlled and especially suited for
students of the cardiovascular system at all levels from
medical/graduate students through senior investigators in related
fields.
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