I Domains in Integrins (Hardcover, 2003 ed.)

In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.
This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

General

Imprint:	Kluwer Academic / Plenum Publishers
Country of origin:	United States
Series:	Molecular Biology Intelligence Unit
Release date:	July 2003
First published:	2003
Editors:	Donald Gullberg
Dimensions:	229 x 152 x 19mm (L x W x T)
Format:	Hardcover
Pages:	186
Edition:	2003 ed.
ISBN-13:	978-0-306-47836-9
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Metabolism Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	0-306-47836-6
Barcode:	9780306478369

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