Books > Science & Mathematics > Biology, life sciences > Cellular biology
|
Buy Now
Cellular Organelles and the Extracellular Matrix, Volume 3 (Hardcover)
Loot Price: R2,769
Discovery Miles 27 690
|
|
Cellular Organelles and the Extracellular Matrix, Volume 3 (Hardcover)
Series: Principles of Medical Biology
Expected to ship within 12 - 17 working days
|
This volume is in two parts. The first contains the remaining
chapters on cellular organelles and several chapters relating to
organelle disorders. An account of mitochondriopathis is given in
the chapter on the mitochondrion rather than in a separate one. The
subject matter of this part of the volume shows quite clearly that
the interdisciplinary approach to the study of organelles has shed
considerable light on the nature of the mechanisms underlying the
etiology and pathobiology of many of these disorders. As an
example, mutations in the genes encoding integral membrane proteins
are found to lead to disturbances in peroxisome assembly. It is
also interesting and significant that mistargeting of protein is
now thought to be another cause. It will be revealing to see
whether mistargeting is the result of mutations in the genes
encoding chaperones.
The second part of the volume is concerned with the extracellular
matrix. It sets out to show that a vast body of new knowledge of
the extracellular matrix is available to us. Take for example the
integrin family of cell adhesion receptors. It turns out that
integrins play a key role not only in adhesion but also in coupling
signals to the nucleus via the cytoskeleton. As for fibronectins,
they seem to link the matrix with the cytoskeleton by interacting
with integrins.
Collagen molecules are dealt with in the last two chapters. The
boundaries of collagen in disease are defined by drawing a clear
line of demarcation between systemic connective tissue disorders
(e.g., scleroderma), better known as autoimmune diseases, and the
heritable, and the heritable diseases such as osteogenesis
imperfect and the Marfan syndrome. This classification takes into
account a second group of acquired disorders of collagen forming
tissues in which regional fibrosis is the hallmark. Liver cirrhosis
and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with
cell chemistry was not easily made. It was based on the view that
most students will have had an undergraduate course in biochemistry
of cell biology or both courses, and that they could go to Volumes
4-7 in which the subject of cell chemistry is covered, and then
return to Volumes 2 and 3.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.