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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)
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Principles of Animal Extrapolation (1991) (Hardcover)
Loot Price: R9,883
Discovery Miles 98 830
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Principles of Animal Extrapolation (1991) (Hardcover)
Series: CRC Press Revivals
Expected to ship within 12 - 17 working days
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Donate to Against Period Poverty
Total price: R9,903
Discovery Miles: 99 030
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Principles of Animal Extrapolation addresses the conceptual basis
for animal extrapolation and provides an abundance of documentation
that illustrates how these principles may be applied in the
selection of the more appropriate models and in the interpretation
of toxicological studies. The book analyzes and documents each
specific biological cause of interspecies differences in
susceptibility to toxic agents, including differences in
absorption, gut flora, tissue distribution, metabolism, mechanisms
and efficiencies of repair, and excretion. The problem of the
heterogenicity of the human population is addressed through several
chapters that assess the availability and prospects of developing
predictive animal models for normal humans, as well as selected
potential high-risk groups. Other topics presented in this book
include the biological basis of regulatory actions involving
attempts to extrapolate from exceptionally high exposure levels to
realistic values, especially carcinogens; an assessment of
genotoxicity tests, their ability to predict carcinogenicity in
whole animals, and the manner in which they should be used by
regulatory agencies; birth defects; and predicting the risk of
human teratogenesis. Principle of Animal Extrapolation is essential
for environmental toxicologists. It also provides valuable
information to biomedical scientists (especially those involved in
drug development and testing) and regulatory personnel in agencies
such as the EPA, the OSHA, the NIOSH, and the FDA.
General
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