A cutting-edge review of the biochemical, physiological,
pharmacological, genetic, and molecular interactions involved in
the development and homeostasis of the skeleton. Topics range from
chondrogenesis, chondrocytes, and cartilage to skeletal
dysmorphology, and include the control of skeletal development,
osteoblastic cell differentiation, and bone induction, growth,
remodeling, and mineralization. The authors' understanding of bone
physiology-and how it is modified throughout all the stages of
life-offers novel approaches for improving the endurance of
load-bearing implants, achieving life-long optimal bone strength,
overcoming microgravity situations (space flight), and hastening
the healing of fractures, osteotomies, and antrodeses.
General
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