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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R1,622
Discovery Miles 16 220
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Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: NATO Science Series A:, 202
Expected to ship within 10 - 15 working days
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This volume represents the proceedings of a NATO Advanced Study
Institute on "Molecular Aspects of Monooxygenases and Bioactivation
of Toxic Compounds" which was held in ~e me (Izmir) Turkey, August
27 to September 7, 1989. The Institute emphasized the potential
dangers of drugs, pollutants, pesticides, carcinogens, and both
nutrient and non-nutrient food additives and their interactions at
the molecular level. These xenobiotics are metabolized in phase I
reactions by monooxygenases, primarly cytochrome P450-isozyme
dependent, followed by phase II conjugation enzymes. The
versatility of these enzymes is unique in biochemistry since they
catalyze the metabolism of an almost limitless number of compounds
through a diverse array of reactions. Although these metabolic
sequences are usually detoxication mechanisms, in some cases the
reactive intermediates are more mutagenic, more carcinogenic and
ultimately more toxic than the parent compound. The Institute was
devoted to recent scientific progress in the understanding of the
biochemical and molecular properties of these enzymes and factors
that influence the metabolism of chemicals to toxic and non-toxic
compounds. Overview lectures focused on xenobiotic metabolism by
cytochrome P450, the flavin-containing monooxygenase, cytochrome
b5, epoxide hydrolase, glutathione S-transferase and
UDP-glucuronosyl transferase. Several additional presentations
stressed various aspects of cytochrome P450 mediated metabolism
including: specific forms in the rabbit and insects; topology in
membranes; posttranslational modification; control of constitutive
forms in the rat; hormonal and xenobiotic regulation; prostanoid
metabolism; endogenous substrate metabolism; interaction with
estrogenic pesticides; pesticide bioactivation. The Institute also
included talks on interactions between enzymes and on benzene
metabolism and toxicity.
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