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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Perspectives in Regenerative Medicine (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,443
Discovery Miles 34 430
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Perspectives in Regenerative Medicine (Paperback, Softcover reprint of the original 1st ed. 2014)
Expected to ship within 10 - 15 working days
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The information given in this book tries to capture the essence of
the sheer dynamicity of the cell along with useful tips on how to
address critical rate limiting steps in the process of exploration
and investigation of its capacity to regenerate, rebuild and
replenish from within. The definitions of stem cells, stemness, and
the niche concept continue to undergo revisions. In adult
vertebrates, hematopoietic and some non-hematopoietic progenitors
are synthesized within specialized niches of bone marrow. They
migrate to designated tissues, and are either trans-differentiated
or become quiescent and settle down. These form the stem cell niche
reservoir in all tissues. Not only the primary hematopoietic tissue
but all organs and tissues are also capable of generating
progenitors which are either synthesized from these migrants or are
direct recruits from other tissues. In the niches, the cells settle
down and await their turn to either make more clones like
themselves or differentiate and mobilize in an exigency. Thus
progenitors are important reserves, to be multiplied and deployed
or travel as important message bearing molecules via blood as
circulating progenitors which can home to their allocated
destinations. Upon reaching, specific integrins and selectins help
them “dock” and “port” and they may be reprogrammed to
induce further differentiation and help repopulate the denuded
tissue. In pulmonary fibrosis and asthma, progenitors from both
systemic circulation and local stem cell niches have been found to
participate in the myriad ramifications of repair, replacement and
regeneration of lost or diseased tissue. Whether they are lung
specific or global in origin and role remain to be explored.
Research tools, fundamental concepts, techniques, methodologies and
standard operating protocols and animal models and human
extrapolations, have been discussed in a concise way along with
detailed description and discussion on the appropriate rationale to
introduce the subject to the casual reader and provide valuable
tactical information to the specialist in Regenerative Medicine. I
sincerely hope you enjoy the work and appreciate the hard work that
has gone into designing and executing elegant experiments by many
researchers in the field. The branch is multi-disciplinary and I
hope that the readers will not be limited to biologists alone.
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