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Bradykinin, Kallidin and Kallikrein (Paperback, Softcover reprint of the original 1st ed. 1970)
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Bradykinin, Kallidin and Kallikrein (Paperback, Softcover reprint of the original 1st ed. 1970)
Series: Handbook of Experimental Pharmacology, 25 / 2
Expected to ship within 10 - 15 working days
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Bradykinin is frequently referred to as an elusive substance; the
editor of a comprehensive volume dealing with kinins thus has a
difficult task. The com plexity of the issues calls for a large
number of contributors who approach the topics from the various
angles that are dictated by the sometimes divergent views of the
individuals. The editor saw no reason to prescribe the mode of
presentation, which was left to the authors and accounts for the
variety of approaches. Contributors from nine countries were asked
to participate in the volume. The chapters were organized to
present, first, the history of the discoveries and methods of
approach to kinin research. Then follows a discussion of the
enzymes that release kinins, their substrates, and other enzymes
that inactivate the peptides. If the release of kinin is important,
then the inhibition of the releasing enzymes is of obvious interest
and is described. Since the measurement of kinin ogen levels in
blood has been frequently used as an indicator of kinin liberation,
in addition to a separate chapter, kininogens are also mentioned
where the functions of kinins are discussed. The conclusions drawn
from establishing structure-action relationships for many analogs
and the actions of kinins are indicated and summarized."
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