Bone Resorption (Hardcover, 2005 ed.)

Bone Resorption, the second volume of the series Topics in Bone Biology, is centered on the osteoclast, the bone-resorbing cell. The volume thus c- plements the ?rst volume of the series, Bone Formation, which discussed origin, function, and pathology of the bone-forming cell, the osteoblast.Both volumes are addressed to scientists and clinicians who are active in or wish to enter the ?eld of skeletal function; this group encompasses a wide variety of specialties, including orthopaedics, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Rubin and Green?eld, in the ?rst chapter, discuss the origin and differ- tiation of the osteoclast. Recognized as a multinuclear cell about 150 years ago, its origin was not uncovered until a century later when, as a result of an experiment in which quail and chicken cells were co-cultured, it became clear that osteoclasts arose from hematopoietic stem cells.The authors then discuss the osteoclastogenic factor, now known as RANKL; the inhibitory binding protein, osteoprotegerin (OPG); and the complex signaling pathway that leads to differentiation and late differentiation of this complicated cell. A section of the chapter is devoted to a concise discussion of regulators and repressors of osteoclast differentiation, including sex steroids, calcitonin, nitric oxide, and mechanical factors. The chapter concludes that the ost- clast modulates bone development, bone growth, and

General

Imprint:	Springer London
Country of origin:	United Kingdom
Series:	Topics in Bone Biology, 2
Release date:	August 2005
First published:	2005
Editors:	Felix Bronner • Mary C. Farach-Carson • Janet Rubin
Dimensions:	254 x 178 x 12mm (L x W x T)
Format:	Hardcover
Pages:	190
Edition:	2005 ed.
ISBN-13:	978-1-85233-812-1
Categories:	Books > Medicine > Surgery > Orthopaedics & fractures
LSN:	1-85233-812-1
Barcode:	9781852338121

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