Bone Resorption, the second volume of the series Topics in Bone
Biology, is centered on the osteoclast, the bone-resorbing cell.
The volume thus c- plements the ?rst volume of the series, Bone
Formation, which discussed origin, function, and pathology of the
bone-forming cell, the osteoblast.Both volumes are addressed to
scientists and clinicians who are active in or wish to enter the
?eld of skeletal function; this group encompasses a wide variety of
specialties, including orthopaedics, rheumatology, endocrinology,
nephrology, oncology, dentistry, nursing, and chiropractic
medicine. Rubin and Green?eld, in the ?rst chapter, discuss the
origin and differ- tiation of the osteoclast. Recognized as a
multinuclear cell about 150 years ago, its origin was not uncovered
until a century later when, as a result of an experiment in which
quail and chicken cells were co-cultured, it became clear that
osteoclasts arose from hematopoietic stem cells.The authors then
discuss the osteoclastogenic factor, now known as RANKL; the
inhibitory binding protein, osteoprotegerin (OPG); and the complex
signaling pathway that leads to differentiation and late
differentiation of this complicated cell. A section of the chapter
is devoted to a concise discussion of regulators and repressors of
osteoclast differentiation, including sex steroids, calcitonin,
nitric oxide, and mechanical factors. The chapter concludes that
the ost- clast modulates bone development, bone growth, and
General
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