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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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Principles of Toxicology Testing (Paperback, 2nd edition)
Loot Price: R4,188
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Principles of Toxicology Testing (Paperback, 2nd edition)
Expected to ship within 12 - 19 working days
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Nationally, toxicology programs have evolved from a traditional
exploration of the chemistry and applied toxicity of chemicals and
drugs to a more comprehensive study of toxicology and toxicology
testing as independent entities. Consequently, the second edition
of Principles of Toxicology Testing starts with basic toxicological
principles, including absorption, distribution, metabolism, and
elimination of toxins, including chemicals and drugs. The book then
continues with animal (in vivo) and in vitro toxicology testing
methods associated with toxicological analysis and preclinical drug
development. As in the first edition, the book begins with an
introduction into the fundamentals of toxicology (Section I) to
prepare readers for the subsequent topics and continues through
with a discussion of toxicokinetics and human risk assessment. This
introductory material is useful in understanding the applications
of toxicology testing. Section II describes the fundamental
principles of toxicology testing in animals in greater detail. This
section describes acute toxicity studies as well as subchronic and
chronic studies performed on animals. Special emphasis is placed on
study design and determination of classical indicators for acute
and chronic testing, such as the LD50. The book examines other
short- and long-term animal toxicity testing methodologies,
including dermal, ocular, and reproductive toxicity testing. In
addition, mutagenicity and carcinogenicity studies are also
discussed in separate chapters. Section III introduces and
discusses in vitro alternatives to animal toxicology tests. This
section emphasizes cell culture methodology and cellular methods
for acute systemic toxicity, target organ toxicity, and local
toxicity. The contributors present the advantages and disadvantages
of alternative methods. They also describe the use of
high-throughput screening and its applications, the concepts of
standardization and validation of in vitro techniques (especially
large, organized validation efforts currently supported by US and
EU regulatory agencies), and the theories supporting the
development of in vitro methodologies. This second edition is a
must-read for undergraduate and graduate toxicology students.
Industrial and academic research centers will also find the text
useful for establishing a toxicology testing laboratory.
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