Adrenergic Mechanisms in Myocardial Ischemia (Paperback, Softcover reprint of the original 1st ed. 1991)

Stress-induced myocardial ischemia is a frequent manifestation of coronary heart disease, and sympathetic activation is an important precipitating and aggravating factor in such stress- induced ischemia. However, the complex interplay between the sympathetic initiation of myocardial ischemia, ischemia-induced alterations in sympathetic neurotransmission, as well as changes in adrenoceptor density and post-receptor signal transduction that can occur during ischemia remains incompletely understood. Not only the activation of myocardial fJ- adrenoceptors, but also the activation of coronary IX-adrenoceptors can contribute to myocar- dial ischemia. However, the role of fJ-adrenoceptor-mediated increases in contractility relative to heart rate in the initiation of ischemia is not clear, and the significance of IX-adrenoceptor- mediated changes in coronary vasomotor tone, as well as the responsible IX-adrenoceptor subtypes are highly controversial. Malignant arrhythmias may be triggered by both IX- and fJ-adrenergic mechanisms. Current research in this field is focussed not only on the underlying physiological and pathophysiological mechanisms, but also on clinical treatment strategies, e. g. , by fJ-blockade, IX-blockade, bradycardic agents and calcium antagonists. Recent findings were presented and future research directions discussed during the 61" International Titisee Conference, held at the Schwarzwald-Hotel, Titisee, March 29-31, 1990 under the sponsorship of the Boehringer Ingelheim Foundation. Dr. Hasso Schroeder and Dr. Hermann Frohlich deserve special thanks for their generous support and pleasant organization of the meeting. The publication of the proceedings has been made possible by grants from Astra Chemicals, Bayer, ICI, Dr. Karl Thomae, and Upjohn.

General

Imprint:	Steinkopff Darmstadt
Country of origin:	Germany
Release date:	October 2013
First published:	1991
Editors:	G Heuch • J. Ross
Dimensions:	244 x 170 x 20mm (L x W x T)
Format:	Paperback
Pages:	376
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-3-662-11040-9
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General
LSN:	3-662-11040-7
Barcode:	9783662110409

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