Stepping ahead of the general front, Volume 41 in the series
"Advances in Enzyme Regulation" moves the studies of mammalian
enzymic and metabolic regulation forward.
This volume was dedicated on the centenary of his birth to Sir Hans
A. Krebs who gave the Special Symposium lectures for 15 years.
George Weber spoke on the joint work he carried out in Oxford with
Krebs and his associates, entitled "Cancer and Clinical
Targeting."
Much of the Symposium centered on novel aspects of signal
transduction, including Inositol Signaling and on
phosphatidylinositol 3'kinase and kinase B. The Special Symposium
Lecture was given on Inositol Lipid Signaling in the Nucleus.
The location and regulation of protein kinases were
discussed.
Clinical aspects of enzyme regulation were presented featuring
studies on dihydrophyrimidine dehydrogenase, development,
citrullinemia and human melanoma heparanase.
Drug targeting and resistance were reviewed featuring etoposide and
tumor vasculature. Regulation of pyruvate dehydrogenase kinase and
abrogration of cytokine-dependency were analyzed. Challenging
results on mRNA stability and apoptosis were presented covering
cyclooxygenase-2 inhibitors, lysosomal cathepsins, human breast
tumors and actin reorganization. The contents listed below provide
a complete overview of topics and speakers.
General
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