The increasing number of patients with chronic diseases implies the
necessity of developing drugs for a longer period and taking a lot
of medicines simultaneously, which may lead to a decrease in
patient compliance. This problem is serious for drugs with short
biological half lives because they must be taken more frequently. A
solution might be the development of a dosage form capable of
releasing the drug gradually. In this regard, microencapsulation
has been used as one of the methods to construct a formulation for
delivering the drug in a controlled mode. This book provides
chemistry of salbutamol sulphate, tramadol hydrochloride,
diclofenac sodium and ethylcellulose, physics of drug release
through particle wall and use of microparticles in life sciences.
Microparticles were prepared by using three different
microencapsulation techniques i.e. coacervation thermal change,
solvent evaporation and coacervation non-solvent addition by
adjusting the ratio of drug to ethylcellulose (release retardant
material). This presentation narrates a complete guideline from
formulation development by microencapsulation to the conductance of
biowaiver study.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
United States |
Release date: |
October 2010 |
First published: |
October 2010 |
Authors: |
Ghulam Murtaza
• Mahmood Ahmad
|
Dimensions: |
229 x 152 x 12mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
216 |
ISBN-13: |
978-3-8383-8412-2 |
Categories: |
Books
|
LSN: |
3-8383-8412-1 |
Barcode: |
9783838384122 |
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