Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Cardiac Management of Oncology Patients - Clinical Handbook for Cardio-Oncology (Paperback, 2015 ed.)
Loot Price: R2,467
Discovery Miles 24 670
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Cardiac Management of Oncology Patients - Clinical Handbook for Cardio-Oncology (Paperback, 2015 ed.)
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This book is designed for clinical cardiologists and other
physicians working with cardiac patients, where specific
specialized teams of cardio-oncologists are not available and who
are called to perform a clinical consultation to evaluate both the
cardiac condition and the eligibility for chemotherapy or
radiotherapy treatment, and to evaluate if a cancer treatment
produces toxic effects on a patient treated with chemo or
radiotherapy and if appearance of new symptoms is due to this
treatment. In recent years, progress in oncologic therapy has
resulted in important developments and the prognostic improvement
of patients with malignancy. The cornerstone of chemotherapy are
the anthracyclines (and the analogue Mitoxantrone), that are direct
cellular toxic agents and that are among the most powerful
anti-neoplastic drugs, but their cardiac toxicity is well known.
Significant breakthroughs in cancer therapy have also been achieved
with the introduction of signalling inhibitors, such as VEGF
inhibitors, HERB2 inhibitors or TK inhibitors used alone or in
combination with direct cellular toxic drugs. However, these
signalling inhibitors may interact also with cardiovascular
signalling and therefore may have functional or structural effects
on the myocardium. This can be permanent or reversible, with
impairment of the global conditions and important side effects, and
increase both morbidity and mortality and worsening of quality of
life. Chemotherapy and radiotherapy can have acute detrimental
effects that can be present for years after treatment and that can
lead to cardiac consequences also after long periods of no clinic
sequelae. Patient numbers with cancer problems will dramatically
increase in the next years and thus every cardiologist will need to
have the correct information and the skills to manage these
situations in the correct way. This book will provide these tools
for them.
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